Cystine-glutamate antiporterxCTas a therapeutic target for cancer

被引：49
作者：
Liu, Lin [1 ]
Liu, Rui [2 ]
Liu, Yi [1 ]
Li, Guanghui [1 ]
Chen, Qing [1 ]
Liu, Xiaodong [1 ]
Ma, Shumei [1 ]
机构：
[1] Wenzhou Med Univ, Platform Radiat Protect & Emergency Preparedness, Sch Publ Hlth & Management, Wenzhou 325035, Peoples R China
[2] Jilin Univ, Key Lab Radiobiol, Minist Hlth, Sch Publ Hlth, Changchun, Peoples R China
来源：
CELL BIOCHEMISTRY AND FUNCTION | 2021年 / 39卷 / 02期
关键词：
cancer; ferroptosis; oxidative stress; system X-c(-); xCT; CYSTINE/GLUTAMATE ANTIPORTER; CELL-PROLIFERATION; SYSTEM X(C)(-); XCT; FERROPTOSIS; CISPLATIN; INHIBITION; TRANSPORT; PROMOTES; SULFASALAZINE;
D O I：
10.1002/cbf.3581
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cystine/glutamic acid reverse transporter (System X-c(-)), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against oxidative stress and ferroptosis. Studies have confirmed that xCT is highly expressed in a variety of tumour and is associated with tumour proliferation, invasion, metastasis, drug resistance and ferroptosis, and can be used as a potential target for tumour treatment. This review provides insights into the biological effects of xCT and contribute to the development of new xCT-based strategies.
引用
收藏
页码：174 / 179
页数：6
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