Functional MRI study of mild Alzheimer's disease using amplitude of low frequency fluctuation analysis

被引:21
作者
Xi Qian [1 ]
Zhao Xiao-hu [1 ]
Wang Pei-jun [1 ]
Guo Qi-hao [2 ]
Yan Chao-gan [3 ]
He Yong [3 ]
机构
[1] Tongji Univ, Dept Radiol, Tongji Hosp, Shanghai 200065, Peoples R China
[2] Fudan Univ, Dept Neurol, Huashan Hosp, Shanghai 200040, Peoples R China
[3] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; resting-state functional MRI; amplitude of low frequency fluctuation; VOXEL-BASED MORPHOMETRY; COGNITIVE IMPAIRMENT; DEFAULT-MODE; BRAIN ACTIVITY; BASE-LINE; CORTEX; CONNECTIVITY; NETWORK; FMRI;
D O I
10.3760/cma.j.issn.0366-6999.2012.05.023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Previous studies have shown that the functional brain activity in the resting state is impaired in Alzheimer's disease (AD) patients. However, most studies focused on the relationship between different brain areas, rather than the amplitude or strength of the regional brain activity. The purpose of this study was to explore the functional brain changes in AD patients by measuring the amplitude of the blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals. Methods Twenty mild AD patients and twenty healthy elderly subjects participated in the fMRI scan. The amplitude of low frequency fluctuation (ALFF) was calculated using REST software. Results Compared with the healthy elderly subjects, the mild AD patients showed decreased ALFF in the right posterior cingulate cortex, right ventral medial prefrontal cortex, and in the bilateral dorsal medial prefrontal cortex. No brain region with increased ALFF was found in the AD group compared with the control group. Conclusions The reduced activity in the posterior cingulate cortex and medial prefrontal cortex observed in the present study suggest that the functional abnormalities of those areas are at an early stage of AD. The ALFF analysis may provide a useful tool in fMRI study of AD. Chin Med J 2012;125(5):858-862
引用
收藏
页码:858 / 862
页数:5
相关论文
共 30 条
  • [1] Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study
    Bai, Feng
    Zhang, Zhijun
    Yu, Hui
    Shi, Yongmei
    Yuan, Yonggui
    Zhu, Wanlin
    Zhang, Xiangrong
    Qian, Yun
    [J]. NEUROSCIENCE LETTERS, 2008, 438 (01) : 111 - 115
  • [2] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI
    BISWAL, B
    YETKIN, FZ
    HAUGHTON, VM
    HYDE, JS
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) : 537 - 541
  • [3] Alzheimer's disease
    Scheltens, Philip
    De Strooper, Bart
    Kivipelto, Miia
    Holstege, Henne
    Chetelat, Gael
    Teunissen, Charlotte E.
    Cummings, Jeffrey
    van der Flier, Wiesje M.
    [J]. LANCET, 2021, 397 (10284) : 1577 - 1590
  • [4] The contribution of voxel-based morphometry in staging patients with mild cognitive impairment
    Bozzali, M.
    Filippi, M.
    Magnani, G.
    Cercignani, M.
    Franceschi, M.
    Schiatti, E.
    Castiglioni, S.
    Mossini, R.
    Falautano, M.
    Scotti, G.
    Comi, G.
    Falini, A.
    [J]. NEUROLOGY, 2006, 67 (03) : 453 - 460
  • [5] The brain's default network - Anatomy, function, and relevance to disease
    Buckner, Randy L.
    Andrews-Hanna, Jessica R.
    Schacter, Daniel L.
    [J]. YEAR IN COGNITIVE NEUROSCIENCE 2008, 2008, 1124 : 1 - 38
  • [6] Cordes D, 2001, AM J NEURORADIOL, V22, P1326
  • [7] Sensitivity and specificity of neuropsychological tests for mild cognitive impairment, vascular cognitive impairment and Alzheimer's disease
    de Jager, CA
    Hogervorst, E
    Combrinck, M
    Budge, MM
    [J]. PSYCHOLOGICAL MEDICINE, 2003, 33 (06) : 1039 - 1050
  • [8] Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    Dickerson, BC
    Salat, DH
    Greve, DN
    Chua, EF
    Rand-Giovannetti, E
    Rentz, DM
    Bertram, L
    Mullin, K
    Tanzi, RE
    Blacker, D
    Albert, MS
    Sperling, RA
    [J]. NEUROLOGY, 2005, 65 (03) : 404 - 411
  • [9] Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
    Fox, Michael D.
    Raichle, Marcus E.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) : 700 - 711
  • [10] Combining EEG and fMRI:: A multimodal tool for epilepsy research
    Gotman, Jean
    Kobayashi, Eliane
    Bagshaw, Andrew P.
    Benar, Christian-G.
    Dubeau, Frangois
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2006, 23 (06) : 906 - 920