Medicinal foodstuffs. XXVIII. Inhibitors of nitric oxide production and new sesquiterpenes, zedoarofuran, 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, from Zedoariae Rhizoma

被引：88

作者：

Matsuda, H ^{[1
]}

Morikawa, T ^{[1
]}

Toguchida, I ^{[1
]}

Ninomiya, K ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 12期

关键词：

zedoarofuran; 4-epicurcumenol; neocurcumenol; gajutsulactone; zedoarolide; Zedoariae Rhizoma;

D O I：

10.1248/cpb.49.1558

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new eudesmane-type sesquiterpene. zedoarofuran, and six new guaiane- or seco-guaiane-type sesquiterpenes. 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, were isolated from aqueous acetone extract of Zedoariae Rhizoma together with 36 known sesquiterpenes and two diarylheptanoids. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The effects of isolated components on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages were examined and 16 sesquiterpenes including gajutsulactones A and B, and bis(4-hydroxy-cinnamoyl)methane were found to show inhibitory activity.

引用

页码：1558 / 1566

页数：9

共 36 条

[11] Bioactive constituents of Chinese natural medicines. VI. Moutan cortex. (2): Structures and radical scavenging effects of suffruticosides A, B, C, D, and E and galloyl-oxypaeoniflorin
Matsuda, H
Ohta, T
Kawaguchi, A
Yoshikawa, M
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (01) : 69 - 72
[12] Hepatoprotective constituents from Zedoariae Rhizoma: Absolute stereostructures of three new carabrane-type sesquiterpenes, curcumenolactones A, B, and C
Matsuda, H
Morikawa, T
Ninomiya, K
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (04) : 909 - 916
[13] Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from Zedoariae Rhizoma
Matsuda, H
Morikawa, T
Ninomiya, K
Yoshikawa, M
[J]. TETRAHEDRON, 2001, 57 (40) : 8443 - 8453
[14] Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: Structure requirement and role of heat shock protein induction
Matsuda, H
Kagerura, T
Toguchida, I
Ueda, H
Morikawa, T
Yoshikawa, M
[J]. LIFE SCIENCES, 2000, 66 (22) : 2151 - 2157
[15] Matsuda H, 2000, CHEM PHARM BULL, V48, P1429, DOI 10.1248/cpb.48.1429
[16] Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa
Matsuda, H
Kageura, T
Inoue, Y
Morikawa, T
Yoshikawa, M
[J]. TETRAHEDRON, 2000, 56 (39) : 7763 - 7777
[17] Matsuda H, 2001, HETEROCYCLES, V55, P841
[18] Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga
Matsuda, H
Murakami, T
Kageura, T
Ninomiya, K
Toguchida, I
Nishida, N
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (16) : 2191 - 2196
[19] Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury
Matsuda, H
Ninomiya, K
Morikawa, T
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (04) : 339 - 344
[20] Effects of sesquiterpenes and triterpenes from the rhizome of Alisma orientale on nitric oxide production in lipopolysaccharide-activated macrophages:: Absolute stereostructures of alismaketones-B 23-acetate and -C 23-acetate
Matsuda, H
Kageura, T
Toguchida, I
Murakami, T
Kishi, A
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (21) : 3081 - 3086

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