Medicinal foodstuffs. XXVIII. Inhibitors of nitric oxide production and new sesquiterpenes, zedoarofuran, 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, from Zedoariae Rhizoma

被引：88

作者：

Matsuda, H ^{[1
]}

Morikawa, T ^{[1
]}

Toguchida, I ^{[1
]}

Ninomiya, K ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 12期

关键词：

zedoarofuran; 4-epicurcumenol; neocurcumenol; gajutsulactone; zedoarolide; Zedoariae Rhizoma;

D O I：

10.1248/cpb.49.1558

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new eudesmane-type sesquiterpene. zedoarofuran, and six new guaiane- or seco-guaiane-type sesquiterpenes. 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, were isolated from aqueous acetone extract of Zedoariae Rhizoma together with 36 known sesquiterpenes and two diarylheptanoids. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The effects of isolated components on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages were examined and 16 sesquiterpenes including gajutsulactones A and B, and bis(4-hydroxy-cinnamoyl)methane were found to show inhibitory activity.

引用

页码：1558 / 1566

页数：9

共 36 条

[1] BEECHAM AF, 1972, TETRAHEDRON LETT, P1669
[2] BEECHAM AF, 1972, TETRAHEDRON, V28, P5542
[3] ENDO J, 1979, CHEM PHARM BULL, V27, P275
[4] HIKINO H, 1975, J CHEM SOC PERK T 1, P478, DOI 10.1039/p19750000478
[5] HIKINO H, 1968, CHEM PHARM BULL, V16, P827
[6] HIKINO H, 1968, CHEM PHARM BULL, V16, P39
[7] Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: Structural requirements of stilbenes for the activity
Kageura, T
Matsuda, H
Morikawa, T
Toguchida, I
Harima, S
Oda, M
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (07) : 1887 - 1893
[8] Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages
Matsuda, H
Kageura, T
Morikawa, T
Toguchida, I
Harima, S
Yoshikawa, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (04) : 323 - 327
[9] Matsuda H, 2002, HETEROCYCLES, V56, P45
[10] Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages
Matsuda, H
Kageura, T
Oda, M
Morikawa, T
Sakamoto, Y
Yoshikawa, M
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (06) : 716 - 720

← 1 2 3 4 →