Circular RNAs in gastric cancer: Biomarkers for early diagnosis

被引：14

作者：

Yang, Chun-Mei ^{[1
,2
]}

Qiao, Guang-Lei ^{[1
]}

Song, Li-Na ^{[1
]}

Bao, Shisan ^{[1
,3
,4
]}

Ma, Li-Jun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Tongren Hosp, Dept Oncol, Sch Med, 1111 Xianxia Rd, Shanghai 200336, Peoples R China

[2] Beihua Univ, Dept Clin Lab Diagnost, Jilin 132012, Jilin, Peoples R China

[3] Univ Sydney, Sch Med Sci, Charles Perkins Ctr, Discipline Pathol, Johns Hopkins Dr, Sydney, NSW 2006, Australia

[4] Univ Sydney, Bosch Inst, Charles Perkins Ctr, Discipline Pathol, Johns Hopkins Dr, Sydney, NSW 2006, Australia

来源：

ONCOLOGY LETTERS | 2020年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

circular RNAs; gastric cancer; novel biomarkers; COLORECTAL-CANCER; NONCODING RNAS; UP-REGULATION; MIGRATION; PROMOTES; PROLIFERATION; PROGRESSION; INVASION; PROTEIN; CELLS;

D O I：

10.3892/ol.2020.11623

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNAs (circRNAs) are highly conserved and stable closed-loop non-coding RNAs. They are involved in numerous biological functions, including regulating gene transcription or protein translation by interacting with proteins and regulating expression of microRNAs. The aberrant expression of circRNAs has been reported in many cancers, including gastric cancer. By regulating gene expression, circRNAs are able to affect the proliferation, invasion and metastasis of gastric cancer. The current review focused on the characteristics and biological functions of circRNAs, the carcinogenic potential and the possible implications of circRNAs on the diagnosis and treatment of gastric cancer. In conclusion, circRNAs may serve as potential biomarkers for diagnosis, as well as therapeutic targets.

引用

页码：465 / 473

页数：9

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