Dynamics of Charged Complex Molecules in Aqueous Solution

被引：0

作者：

Gasparyan, F., V ^{[1
]}

Gasparyan, L. F. ^{[1
,2
]}

Simonyan, V. V. ^{[2
]}

机构：

[1] Yerevan State Univ, Yerevan, Armenia

[2] DNA HIVE LLC, Rockville, MD USA

来源：

JOURNAL OF CONTEMPORARY PHYSICS-ARMENIAN ACADEMY OF SCIENCES | 2022年 / 57卷 / 01期

关键词：

DNA molecule; sequencing; tunnel current; DNA reading; REAL-TIME DETECTION; DNA TRANSLOCATION; NUCLEIC-ACIDS; NANOPORE; IDENTIFICATION; NUCLEOTIDES; ANTIBODY; PROTEIN;

D O I：

10.3103/S1068337222010091

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The results of theoretical modeling of the dynamics of a charged large molecule in an aqueous solution under the influence of gravity, vertical electric field, and drag force are presented. Computations were carried out for the DNA molecule. It is shown that one can smoothly control the speed of movement of a molecule by an electric field so that it is possible to carry out accurate sequencing by the tunneling current method. It was also shown that the speed of movement of a molecule can be reduced to some decimal cm/s, which is equivalent to sequencing 10(5)-10(6) nucleoids per second.

引用

页码：98 / 103

页数：6

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