Corneal Topography and in vivo Confocal Microscopy in Different Types of Posterior Polymorphous Dystrophy

To observe the morphologic changes in the corneas of patients with posterior polymorphous dystrophy (PPMD), using in vivo confocal microscopy and Orbscan. corneal topography. Four patients with clinical diagnosis of PPMD, presenting to the Henan Institute of Ophthalmology, were included in this observational case series. The eyes of the 4 patients were examined by slit-lamp biomicroscopy, Orbscan. corneal topography, and in vivo confocal microscopy. Two patients presented with corneal steepening on topography, as well as large areas of irregular polymorphous changes of the corneal endothelium on in vivo confocal microscopy consistent with PPMD. Confocal microscopy demonstrated craters, streaks, and cracks over the corneal endothelium surface. Pleomorphism and polymegathism were present in eyes with PPMD. Guttata and clusters of abnormal endothelial cells were also identified in corneas of these PPMD patients. In vivo confocal microscopy is potentially useful for monitoring of disease progression and excluding suspected cases of subclinical PPMD. Abnormalities on the corneal topography were observed, this report brings forth the descriptions of morphologic changes on Orbscan topography. [Weihong Zhang, Jingjing Wang, Jinguo Wang, Yang Jing. Corneal Topography and in vivo Confocal Microscopy in Different Types of Posterior Polymorphous Dystrophy. Life Science Journal. 2011;8(2):227-238] (ISSN: 10978135). http://www.lifesciencesite.com.