Mouse mutants as models for congenital retinal disorders

被引：64

作者：

Dalke, C ^{[1
]}

Graw, J ^{[1
]}

机构：

[1] GSF, Natl Res Ctr Environm & Hlth, Inst Dev Genet, D-85764 Neuherberg, Germany

来源：

EXPERIMENTAL EYE RESEARCH | 2005年 / 81卷 / 05期

关键词：

animal model; retina; mouse; gene mutation; retinal degeneration;

D O I：

10.1016/j.exer.2005.06.004

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Animal models provide a valuable tool for investigating the genetic basis and the pathophysiology of human diseases, and to evaluate therapeutic treatments. To study congenital retinal disorders, mouse mutants have become the most important model organism. Here we review some mouse models, which are related to hereditary disorders (mostly congenital) including retinitis pigmentosa, Leber's congenital amaurosis, macular disorders and optic atrophy. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：503 / 512

页数：10

共 82 条

[1] A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse [J].

Akhmedov, NB ;

Piriev, NI ;

Chang, B ;

Rapoport, AL ;

Hawes, NL ;

Nishina, PM ;

Nusinowitz, S ;

Heckenlively, JR ;

Roderick, TH ;

Kozak, CA ;

Danciger, M ;

Davisson, MT ;

Farber, DB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5551-5556

[2] Impairment of the transient pupillary light reflex in Rpe65-/- mice and humans with Leber congenital amaurosis [J].

Aleman, TS ;

Jacobson, SG ;

Chico, JD ;

Scott, ML ;

Cheung, AY ;

Windsor, EAM ;

Furushima, M ;

Redmond, TM ;

Bennett, J ;

Palczewski, K ;

Cideciyan, AV .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (04) :1259-1271

[3] An in vivo doxycycline-controlled expression system for functional studies of the retina [J].

Angeletti, B ;

Löster, J ;

Auricchio, A ;

Gekeler, F ;

Shinoda, K ;

Ballabio, A ;

Graw, J ;

Marigo, V .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (02) :755-760

[4] An animal model for Norrie disease (ND): Gene targeting of the mouse ND gene [J].

Berger, W ;

vandePol, D ;

Bachner, D ;

Oerlemans, F ;

Winkens, H ;

Hameister, H ;

Wieringa, B ;

Hendriks, W ;

Ropers, HH .

HUMAN MOLECULAR GENETICS, 1996, 5 (01) :51-59

[5] Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3 [J].

Biel, M ;

Seeliger, M ;

Pfeifer, A ;

Kohler, K ;

Gerstner, A ;

Ludwig, A ;

Jaissle, G ;

Fauser, S ;

Zrenner, E ;

Hofmann, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7553-7557

[6] LOCALIZATION OF A RETROVIRAL ELEMENT WITHIN THE RD GENE CODING FOR THE BETA-SUBUNIT OF CGMP PHOSPHODIESTERASE [J].

BOWES, C ;

LI, TS ;

FRANKEL, WN ;

DANCIGER, M ;

COFFIN, JM ;

APPLEBURY, ML ;

FARBER, DB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2955-2959

[7]

Bronson RT, 1998, AM J MED GENET, V77, P289, DOI 10.1002/(SICI)1096-8628(19980526)77:4<289::AID-AJMG8>3.0.CO

[8]

2-I

[9] Retinal degeneration mutants in the mouse [J].

Chang, B ;

Hawes, NL ;

Hurd, RE ;

Davisson, MT ;

Nusinowitz, S ;

Heckenlively, JR .

VISION RESEARCH, 2002, 42 (04) :517-525

[10]

Chang MA, 2000, INVEST OPHTH VIS SCI, V41, P4281

← 1 2 3 4 5 6 7 8 9 →