Synthesis, crystal structure, electrochemistry and antioxidative activity of copper(II), manganese(II) and nickel(II) complexes containing bis(N-ethylbenzimidazol-2-ylmethyl)aniline

被引：40

作者：

Wu, Huilu ^{[1
]}

Peng, Hongping ^{[1
]}

Zhang, Yanhui ^{[1
]}

Wang, Fei ^{[1
]}

Zhang, Han ^{[1
]}

Wang, Cuiping ^{[1
]}

Yang, Zaihui ^{[1
]}

机构：

[1] Lanzhou Jiaotong Univ, Sch Chem & Biol Engn, Lanzhou 730070, Gansu, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2015年 / 29卷 / 07期

基金：

中国国家自然科学基金;

关键词：

benzimidazole; transition metal complexes; crystal structure; electrochemical property; antioxidation; DNA-BINDING PROPERTIES; SUPEROXIDE-DISMUTASE ACTIVITY; METAL-ORGANIC FRAMEWORKS; COBALT(II) COMPLEXES; DERIVATIVES; CYTOTOXICITY; DISCRETE; EPR;

D O I：

10.1002/aoc.3313

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Bis(N-ethylbenzimidazol-2-ylmethyl)aniline (Etbba) and its transition metal complexes, [Cu(Etbba)(Cl)(2)]DMF (1), [Mn(Etbba)(Cl)(2)] (2) and [Ni(Etbba)(Cl)(2)] (3), have been synthesized and characterized on the basis of elemental analysis, molar conductivity, UV-visible, infrared and NMR spectroscopies and X-ray crystallography. The coordination environment of complex 1 can be described as distorted square-based pyramidal, while complexes 2 and 3 each have a distorted trigonal bipyramidal geometry. Cyclic voltammograms of complex 1 indicate an electrochemically quasi-reversible Cu2+/Cu+ couple. In addition, the antioxidant activities of the free ligand and its complexes were investigated using the superoxide and hydroxyl radical scavenging methods in vitro. Complexes 1, 2, 3 are found to possess potent hydroxyl radical scavenging activity and to be better than standard antioxidants like vitamin C and mannitol. Furthermore, complexes 1 and 2 exhibit significant superoxide radical activity. Copyright (c) 2015 John Wiley & Sons, Ltd.

引用

页码：443 / 449

页数：7

共 41 条

[11] Synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents [J].

Gellis, Armand ;

Kovacic, Herve ;

Boufatah, Narimene ;

Vanelle, Patrice .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (09) :1858-1864

[12] The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan [J].

Guo, ZY ;

Xing, RE ;

Liu, S ;

Yu, HH ;

Wang, PB ;

Li, CP ;

Li, PC .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (20) :4600-4603

[13] Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers [J].

Guven, Ozden Ozel ;

Erdogan, Taner ;

Goker, Hakan ;

Yildiz, Sulhiye .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) :2233-2236

[14] The combinatorial synthesis of bicyclic privileged structures or privileged substructures [J].

Horton, DA ;

Bourne, GT ;

Smythe, ML .

CHEMICAL REVIEWS, 2003, 103 (03) :893-930

[15] Ligand-directed strategy for zeolite-type metal-organic frameworks: Zinc(II) imidazolates with unusual zeolitic topologies [J].

Huang, XC ;

Lin, YY ;

Zhang, JP ;

Chen, XM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (10) :1557-1559

[16] Manganese complexes displaying superoxide dismutase activity: A balance between different factors [J].

Iranzo, Olga .

BIOORGANIC CHEMISTRY, 2011, 39 (1-3) :73-87

[17] Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii [J].

Kopanska, K ;

Najda, A ;

Zebrowska, J ;

Chomicz, L ;

Piekarczyk, J ;

Myjak, P ;

Bretner, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (10) :2617-2624

[18] Synthesis, structure and SOD-like activity of a ternary Cu(II) complex with 1,10-phenanthroline and L-valinate [J].

Le, Xueyi ;

Liao, Shenrong ;

Liu, Xiaopin ;

Feng, Xiaolong .

JOURNAL OF COORDINATION CHEMISTRY, 2006, 59 (09) :985-995

[19] Self-assembly of discrete cyclic nanostructures mediated by transition metals [J].

Leininger, S ;

Olenyuk, B ;

Stang, PJ .

CHEMICAL REVIEWS, 2000, 100 (03) :853-907

[20] Synthesis, characterization, antioxidant activity and DNA-binding studies of two rare earth(III) complexes with naringenin-2-hydroxy benzoyl hydrazone ligand [J].

Li, Tian-Rong ;

Yang, Zheng-Yin ;

Wang, Bao-Dui ;

Qin, Dong-Dong .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (08) :1688-1695

← 1 2 3 4 5 →