Development and validation of a high-performance liquid chromatography method using diode array detection for the simultaneous quantification of aripiprazole and dehydro-aripiprazole in human plasma

被引：34

作者：

Lancelin, Frederique ^{[1
]}

Djebrani, Kayssa ^{[2
]}

Tabaouti, Khalid

Kraoul, Linda

Brovedani, Sophie

Paubel, Pascal ^{[2
]}

Piketty, Marie-Liesse

机构：

[1] Ctr Hosp St Anne, Cent Lab, Dept Biol, F-75014 Paris, France

[2] Ctr Hosp St Anne, Paris, France

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 867卷 / 01期

关键词：

aripiprazole; dehydro-aripiprazole; HPLC; therapeutic drug monitoring;

D O I：

10.1016/j.jchromb.2008.02.026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-performance liquid chromatography method with diode array detection (HPLC-DAD) was developed for quantification of aripiprazole and dehydro-aripiprazole, in human plasma. After a simple liquid-liquid extraction, chromatographic separation was carried out on a C18 reversed-phase column, using an ammonium buffer-acetonitrile mobile phase (40:60, v/v). The total run time was only 7 min at a flow-rate of 1.0ml/min. The precision values were less than 12% and the accuracy values were ranging from 98 to 113% and the lower limit of quantification was 2 ng/ml for both compounds. Calibration curves were linear over a range of 2-1000 ng/ml. The mean trough plasma concentrations in patients treated with aripiprazole were 157 and 29 ng/ml for aripiprazole and dehydro-aripiprazole, respectively. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：15 / 19

页数：5

共 14 条

[1] Therapeutic monitoring of psychotropic drugs -: An outline of the AGNP-TDM Expert Group Consensus Guideline [J].

Baumann, P ;

Hiemke, C ;

Ulrich, S ;

Rao, GML ;

Eckermann, G ;

Gerlach, M ;

Kuss, HJ ;

Laux, G ;

Müller-Oerlinghausen, B ;

Rieder, P ;

Zernig, G .

THERAPEUTIC DRUG MONITORING, 2004, 26 (02) :167-170

[2]

*BRIST MYERS SQUIB, 2006, AB AR TABL PRESCR IN

[3]

Food-and-Drug-Administration Center for Drug Evaluation and Research, 2001, GUID IND BIOAN METH

[4]

Gupta Sanjay, 2004, Ann Clin Psychiatry, V16, P155, DOI 10.1080/10401230490487007

[5] Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography-mass spectrometry in blood samples of psychiatric patients [J].

Huang, Hui-Ching ;

Liu, Chin-Hung ;

Lan, Tsuo-Hung ;

Hu, Tsung-Ming ;

Chiu, Hsien-Jane ;

Wu, Yu-Chun ;

Tseng, Ying Lung .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 856 (1-2) :57-61

[6] The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor [J].

Jordan, S ;

Koprivica, V ;

Chen, RY ;

Tottori, K ;

Kikuchi, T ;

Altar, CA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 441 (03) :137-140

[7] Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection [J].

Kirschbaum, KM ;

Müller, MJ ;

Zernig, G ;

Saria, A ;

Mobascher, A ;

Malevani, J ;

Hiemke, C .

CLINICAL CHEMISTRY, 2005, 51 (09) :1718-1721

[8] Development and validation of an LC-MS/MS method for the quantitative determination of aripiprazole and its main metabolite, OPC-14857, in human plasma [J].

Kubo, M ;

Mizooku, Y ;

Hirao, Y ;

Osumi, T .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2005, 822 (1-2) :294-299

[9]

Kubo Masanori, 2005, Drug Metab Pharmacokinet, V20, P55, DOI 10.2133/dmpk.20.55

[10] Dopamine partial agonists - A new class of antipsychotic [J].

Lieberman, JA .

CNS DRUGS, 2004, 18 (04) :251-267

← 1 2 →