The role of genetics for biomarker development in neurodegeneration

被引：19

作者：

Bertram, Lars ^{[1
]}

Hampel, Harald ^{[2
]}

机构：

[1] Max Planck Inst Mol Genet, Dept Vertebrate Genom, Neuropsychiat Genet Grp, D-14195 Berlin, Germany

[2] Goethe Univ Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

来源：

PROGRESS IN NEUROBIOLOGY | 2011年 / 95卷 / 04期

关键词：

Neurodegenerative disease genetics; Alzheimer's disease; Parkinson's disease; Frontotemporal dementia; Amyotrophic lateral sclerosis; Genetic association; Genome-wide association study; Genetic profiling; Genomic profiling; Risk prediction; Biomarker; GENOMIC MEDICINE; ASSOCIATION;

D O I：

10.1016/j.pneurobio.2011.09.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Research on biomarkers and genetics shares a number of objectives, including the identification of novel disease mechanisms, optimization of therapeutic studies, and improvement of diagnosis and prognosis. The latter is of particular relevance in neurodegenerative diseases where the underlying molecular processes often go on for decades until the first clinical symptoms appear. In this commentary we review the potential contribution that insight gained from genetic research may have on biomarker development in neurodegeneration. We argue that future progress will largely depend on a widespread application of novel high-throughput technologies now becoming available in both fields. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：501 / 504

页数：4

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