Anti-inflammatory effects of fructose-1,6-bisphosphate on carrageenan-induced pleurisy in rat

被引：21

作者：

Alves, JCF ^{[1
]}

Santos, RCV ^{[1
]}

Castaman, TA ^{[1
]}

de Oliveira, JR ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Lab Pesquisa Biofis, Dept Ciencias Fisiol, Fac Biociencias, BR-1429 Porto Alegre, RS, Brazil

来源：

PHARMACOLOGICAL RESEARCH | 2004年 / 49卷 / 03期

关键词：

fructose-1,6-bisphosphate; pleurisy; inflammation;

D O I：

10.1016/j.phrs.2003.10.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study, we evaluated the effect of fructose-1,6-bisphosphate (FBP), a high energy intermediate metabolite of glycolysis, in an acute model of lung injury. Injection of carrageenan into the pleural cavity of rats elicited an acute inflammation response characterized by a fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear neutrophils. FBP (500 mg/kg) attenuated the inflammation parameters: exudate volume, total leukocytes and the number of polymorphonuclear leukocytes, but the protein concentration in the exudate was not significantly affected by treatment with FBP. The precise site and mechanism of the anti-inflammatory effect was not addressed, considering the diverse pharmacological actions of FBP. This drug has anti-inflammatory actions suggesting that it may represent a novel strategy for the modulation of inflammatory response. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：245 / 248

页数：4

共 22 条

[1] Fructose-1,6-diphosphate attenuates prostaglandin E2 production and cyclo-oxygenase-2 expression in UVB-irradiated HaCaT keratinocytes [J].