Supramolecular Reaggregation of Acetyl Salicylic Acid-4,4′Dipyridyl Cocrystals from Salicylic Acid-4,4′Dipyridyl Cocrystals

被引：2
作者：
Lee, Kyeong-Sill [1 ,2 ]
Kim, Kwang-Joo [1 ]
Ulrich, Joachim [2 ]
机构：
[1] Hanbat Natl Univ, Dept Chem Engn, Crystallizat Proc & Engn Lab, San 16-1 Dukmyung Dong, Daejeon 305719, South Korea
[2] Univ Halle Wittenberg, Zentrum Ingn Wissensch Verfahrenstech TVT, Halle, Germany
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2016年 / 39卷 / 07期
关键词：
Acetyl salicylic acid; Chemical reactivity; Cocrystals; Cooling crystallization; Salicylic acid; ASPIRIN; DISSOLUTION;
D O I：
10.1002/ceat.201600042
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Screening of the change mechanism of salicylic acid-4,4'dipyridyl (SAA-4,4'dipy) cocrystals to acetyl salicylic acid-4,4'dipyridyl (ASA-4,4'dipy) cocrystals was performed and their transformation investigated. Cocrystals of SAA-4,4'dipy are concomitantly formed in ASA/4,4'dipyridyl/ethanol solutions, resulting from ASA decomposition. Eventually, cocrystals of ASA-4,4'dipy are obtained from a sequence of in situ reactions by controlling the operating conditions. Both cocrystals have the same hydrogen bonding interaction between the drug molecules. The ketene functional group decomposed in salicylic acid cocrystal formation reaggregates during solution-mediated cocrystallization that leads to the formation of ASA cocrystals.
引用
收藏
页码：1257 / 1262
页数：6
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