[11]Cocaine:: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy

被引:55
作者
Fowler, JS [1 ]
Volkow, ND
Wang, GJ
Gatley, SJ
Logan, J
机构
[1] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA
[2] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA
关键词
cocaine; carbon-11; C-11]cocaine; dopamine transporter; Logan plot; PET;
D O I
10.1016/S0969-8051(01)00211-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [C-11]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that it is also a sensitive radiotracer for dopamine transporter (DAT) availability. Measures of DAT availability were facilitated by the development of a graphical analysis method (Logan Plot) for reversible systems which streamlined kinetic analysis. This expanded the applications of [C-11]cocaine to studies of DAT availability in the human brain and allowed the first comparative measures of the degree of DAT occupancy by cocaine and another stimulant drug methylphenidate. This article will summarize preclinical and clinical research with [C-11]cocaine. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:561 / 572
页数:12
相关论文
共 75 条
  • [51] SHARKEY J, 1988, J PHARMACOL EXP THER, V246, P1048
  • [52] COCAINE BINDING AT SIGMA-RECEPTORS
    SHARKEY, J
    GLEN, KA
    WOLFE, S
    KUHAR, MJ
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 149 (1-2) : 171 - 174
  • [53] SPEALMAN RD, 1983, J PHARMACOL EXP THER, V225, P509
  • [54] Talairach J., 1988, Co-planar stereotactic atlas of the human brain
  • [55] MONOAMINE RE-UPTAKE SITES IN THE HUMAN-BRAIN EVALUATED INVIVO BY MEANS OF C-11-NOMIFENSINE AND POSITRON EMISSION TOMOGRAPHY - THE EFFECTS OF AGE AND PARKINSONS-DISEASE
    TEDROFF, J
    AQUILONIUS, SM
    HARTVIG, P
    LUNDQVIST, H
    GEE, AG
    UHLIN, J
    LANGSTROM, B
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 1988, 77 (03): : 192 - 201
  • [56] Telang FW, 1999, SYNAPSE, V31, P290, DOI 10.1002/(SICI)1098-2396(19990315)31:4<290::AID-SYN7>3.0.CO
  • [57] 2-G
  • [58] VOLKOW ND, 1995, J NUCL MED, V36, P1289
  • [59] Volkow ND, 2000, LIFE SCI, V67, pPL1507
  • [60] Volkow ND, 1996, SYNAPSE, V24, P399, DOI 10.1002/(SICI)1098-2396(199612)24:4<399::AID-SYN7>3.0.CO