Problems with the use of breast conservation therapy for breast cancer in a patient with neurofibromatosis type 1: A case report

被引：11

作者：

Hasson, Danielle M. ^{[1
]}

Khera, Samira Y. ^{[1
]}

Meade, Tammi L. ^{[1
]}

Dupont, Elisabeth L. ^{[1
]}

Greenberg, Harvey M. ^{[2
]}

Diaz, Nils M.

Romilly, A. Pat ^{[3
]}

Cox, Charles E. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Comprehens Breast Canc Program, Dept Surg, Tampa, FL 33612 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Comprehens Breast Canc Program, Dept Radiat Oncol, Tampa, FL 33612 USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Comprehens Breast Canc Program, Dept Radiol, Tampa, FL 33612 USA

来源：

BREAST JOURNAL | 2008年 / 14卷 / 02期

关键词：

breast cancer; breast conservation therapy; neurofibromatosis; radiation therapy; von Recklinghausen's disease;

D O I：

10.1111/j.1524-4741.2007.00552.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with Neurofibromatosis type I and breast cancer represent a subset of people who may be considered at high risk for secondary cancers after conventional whole breast radiation therapy and breast conservation surgery. A case of a 49-year-old woman with neurofibromatosis type I is presented. She was diagnosed with a 1.1-cm right breast infiltrating ductal carcinoma. Clinical, diagnostic imaging, and pathologic features are discussed. Her initial treatment plan of breast conserving therapy was thwarted when her sentinel node biopsy was positive for micrometastatic disease in 1/14 lymph nodes. She elected to have a bilateral simple mastectomy. This case addresses the rare dilemma of offering breast conservation therapy as a viable option for patients with neurofibromatosis type I. Current data on radiation-induced secondary cancers such as sarcoma after treatment for breast and other cancers are reviewed.

引用

页码：188 / 192

页数：5

共 13 条

[1] CASE-REPORT - NEUROFIBROSARCOMA AT IRRADIATION SITE IN A PATIENT WITH NEUROFIBROMATOSIS AND WILMS TUMOR [J].