Clinical and molecular characteristics of community-acquired Clostridium difficile infections in comparison with those of hospital-acquired C. difficile

被引：15
作者：
Kwon, Soon Sung [1 ,2 ]
Gim, Jung Lim [1 ,2 ]
Kim, Myung Sook [1 ,2 ]
Kim, Heejung [1 ,2 ]
Choi, Jun Yong [3 ]
Yong, Dongeun [1 ,2 ]
Lee, Kyungwon [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea
[2] Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea
来源：
ANAEROBE | 2017年 / 48卷
关键词：
Clostridium difficile; Community-acquired; Risk factors; Outcome; PCR-ribotypes; PCR RIBOTYPE 018; ANTIMICROBIAL RESISTANCE; SOUTH-KOREA; EPIDEMIOLOGY; EMERGENCE; FEATURES; TOXIN; PREDOMINANCE; MULTICENTER; OUTCOMES;
D O I：
10.1016/j.anaerobe.2017.06.014
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Community-acquired Clostridium difficile infection (CA-CDI) is a growing concern. CA-CDI differs from hospital-acquired C difficile infection (HA-CDI) in its epidemiology, risk factors, severity, and outcomes. In this study, we investigated C. difficile infections in a tertiary care hospital in Seoul, Korea, and compared the CA-CDI and HA-CDI cases diagnosed in the same period. Total 593 cases were confirmed as CDI in 2014, of which CA-CDI accounted for 68 (11.5%) of the total CDI cases. Compared with HA-CDI, the mean age of CA-CDI cases was lower than that of HA-CDI (42.7 vs 60.4). In CA-CDI, antibiotic and proton pump inhibitor (PPI) use in the 12 preceding weeks and concurrent chemotherapy and tube feeding were less frequent compared with HA-CDI. In most cases (63/68, 92.6%), patients with CA-CDI recovered without any complications or recurrence. The most prevalent C. difficile type in CA-CDI cases was PCR-ribotype 012, accounting for 18.3% of the total, followed by PCR-ribotype 018 (16.7%). (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：42 / 46
页数：5
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