Cobalt-catalyzed C-H annulation of N-aroylpicolinamides with alkynes for (NH)-isoquinolones synthesis

被引：2
|
作者：
Wang, Siqi [1 ]
Yao, Lingyun [1 ]
Wang, Jian-Shu [1 ]
Ying, Jun [1 ]
Wu, Xiao-Feng [2 ,3 ]
机构：
[1] Zhejiang Sci Tech Univ, Dept Chem, Key Lab Surface & Interface Sci Polymer Mat Zheji, Hangzhou 310018, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China
[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany
来源：
MOLECULAR CATALYSIS | 2022年 / 524卷
关键词：
cobalt catalyst; isoquinolones; alkyne; annulation; heterocycle synthesis; ACTIVATION; ANALOGS; AMIDES;
D O I：
10.1016/j.mcat.2022.112303
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A cobalt-catalyzed C-H annulation of N-aroylpicolinamides with alkynes has been developed for the construction of (NH)-isoquinolone scaffolds. The reaction employs picolinamide as a traceless directing group and provides a facile and straightforward approach to access various (NH)-isoquinolone derivatives in good yields.
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页数：4
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