Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

被引：53

作者：

Colby, Donn J. ^{[1
]}

Sarnecki, Michal ^{[2
]}

Barouch, Dan H. ^{[3
]}

Tipsuk, Somporn ^{[1
]}

Stieh, Daniel J. ^{[4
]}

Kroon, Eugene ^{[1
]}

Schuetz, Alexandra ^{[5
,6
,7
]}

Intasan, Jintana ^{[1
]}

Sacdalan, Carlo ^{[1
]}

Pinyakorn, Suteeraporn ^{[6
,7
]}

Grandin, Pornsuk ^{[5
]}

Song, Hongshuo ^{[6
,7
,8
]}

Tovanabutra, Sodsai ^{[6
,7
]}

Shubin, Zhanna ^{[6
,7
]}

Kim, Dohoon ^{[6
,7
]}

Paquin-Proulx, Dominic ^{[6
,7
]}

Eller, Michael A. ^{[6
,7
]}

Thomas, Rasmi ^{[6
,7
]}

de Souza, Mark ^{[1
,7
]}

Wieczorek, Lindsay ^{[7
]}

Polonis, Victoria R. ^{[7
]}

Pagliuzza, Amelie ^{[9
,10
]}

Chomont, Nicolas ^{[9
,10
]}

Peter, Lauren ^{[3
]}

Nkolola, Joseph P. ^{[3
]}

Vingerhoets, Johan ^{[11
]}

Truyers, Carla ^{[11
]}

Pau, Maria G. ^{[4
]}

Schuitemaker, Hanneke ^{[4
]}

Phanuphak, Nittaya ^{[1
]}

Michael, Nelson ^{[6
,7
]}

Robb, Merlin L. ^{[6
,7
]}

Tomaka, Frank L. ^{[12
]}

Ananworanich, Jintanat ^{[1
,6
,7
,13
]}

机构：

[1] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand

[2] Janssen Vaccines, Bern, Switzerland

[3] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[4] Janssen Vaccines & Prevent BV, Leiden, Netherlands

[5] Armed Forces Res Inst Med Sci, Bangkok, Thailand

[6] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA

[7] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[8] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[9] CHUM, Ctr Rech, Montreal, PQ, Canada

[10] Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada

[11] Janssen Pharmaceut NV, Beerse, Belgium

[12] Janssen Res & Dev, Titusville, NJ USA

[13] Univ Amsterdam, Dept Global Hlth, Amsterdam, Netherlands

来源：

NATURE MEDICINE | 2020年 / 26卷 / 04期

关键词：

CELLULAR IMMUNE-RESPONSES; AIDS; INDIVIDUALS; REPLICATION; TRIAL; ASSAY;

D O I：

10.1038/s41591-020-0774-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We administered Ad26, modified vaccinia Ankara vectors containing mosaic HIV-1 antigens or placebo in 26 individuals who initiated antiretroviral therapy during acute human immunodeficiency virus infection as an exploratory study to determine the safety and duration of viremic control after treatment interruption. The vaccine was safe and generated robust immune responses, but delayed time to viral rebound compared to that in placebo recipients by only several days and did not lead to viremic control after treatment interruption (clinical trial NCT02919306). Test of therapeutic mosaic vaccines in HIV-infected individuals shows no control of virus after treatment interruption.

引用

页码：498 / +

页数：19

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