Cancer associated fibroblasts in hematological malignancies

被引：39
作者：
Raffaghello, Lizzia [1 ]
Vacca, Angelo [2 ]
Pistoia, Vito [1 ]
Ribatti, Domenico [3 ,4 ]
机构：
[1] Ist Giannina Gaslini, Lab Oncol, Genoa, Italy
[2] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Bari, Italy
[3] Univ Bari, Sch Med, Dept Basic Med Sci Neurosci & Sensory Organs, Bari, Italy
[4] Natl Canc Inst Giovanni Paolo II, Bari, Italy
来源：
ONCOTARGET | 2015年 / 6卷 / 05期
关键词：
cancer associated fibroblasts; mesenchymal stromal cells; hematological malignancies; tumor microenvironment; MESENCHYMAL STEM-CELLS; LYMPHOBLASTIC-LEUKEMIA CELLS; BONE-MARROW FIBROSIS; STROMAL CELLS; GENETIC ABNORMALITIES; TUMOR-GROWTH; HUMAN BREAST; LYMPH-NODES; B-CELLS; ACTIVATION;
D O I：
10.18632/oncotarget.2661
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor microenvironment plays an important role in cancer initiation and progression. In hematological malignancies, the bone marrow represents the paradigmatic anatomical site in which tumor microenvironment expresses its morphofunctional features. Among the cells participating in the composition of this microenvironment, cancer associated fibrobasts (CAFs) have received less attention in hematopoietic tumors compared to solid cancers. In this review article, we discuss the involvement of CAFs in progression of hematological malignancies and the potential targeting of CAFs in a therapeutic perspective.
引用
收藏
页码：2589 / 2603
页数：15
相关论文
共 111 条
[1]   Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure [J].
Abkowitz, JL ;
Robinson, AE ;
Kale, S ;
Long, MW ;
Chen, J .
BLOOD, 2003, 102 (04) :1249-1253
[2]   Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor [J].
Aldinucci, D ;
Poletto, D ;
Nanni, P ;
Degan, M ;
Gloghini, A ;
Di Francia, R ;
Russo, S ;
Carbone, A ;
Pinto, A ;
Gattei, V .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (04) :1055-1064
[3]   Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms [J].
Avanzini, M. A. ;
Bernardo, M. E. ;
Novara, F. ;
Mantelli, M. ;
Poletto, V. ;
Villani, L. ;
Lenta, E. ;
Ingo, D. M. ;
Achille, V. ;
Bonetti, E. ;
Massa, M. ;
Campanelli, R. ;
Fois, G. ;
Catarsi, P. ;
Gale, R. P. ;
Moretta, A. ;
Aronica, A. ;
Maccario, R. ;
Acquafredda, G. ;
Lisini, D. ;
Zecca, M. ;
Zuffardi, O. ;
Locatelli, F. ;
Barosi, G. ;
Rosti, V. .
LEUKEMIA, 2014, 28 (08) :1742-1745
[4]   The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL) [J].
Aziz, KA ;
Till, KJ ;
Chen, HJ ;
Slupsky, JR ;
Campbell, F ;
Cawley, JC ;
Zuzel, M .
BLOOD, 2003, 102 (03) :1051-1056
[5]   Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells [J].
Balakrishnan, Kumudha ;
Burger, Jan A. ;
Quiroga, Maite P. ;
Henneberg, Marina ;
Ayres, Mary L. ;
Wierda, William G. ;
Gandhi, Varsha .
BLOOD, 2010, 116 (07) :1083-1091
[6]   Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].
Balkwill, F ;
Charles, KA ;
Mantovani, A .
CANCER CELL, 2005, 7 (03) :211-217
[7]   Inflammation and cancer: back to Virchow? [J].
Balkwill, F ;
Mantovani, A .
LANCET, 2001, 357 (9255) :539-545
[8]   Tumor microenvironment: Bone marrow-mesenchymal stem cells as key players [J].
Barcellos-de-Souza, Pedro ;
Gori, Valentina ;
Bambi, Franco ;
Chiarugi, Paola .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2013, 1836 (02) :321-335
[9]   CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders:: a review [J].
Béné, MC ;
Castoldi, G ;
Knapp, W ;
Rigolin, GM ;
Escribano, L ;
Lemez, P ;
Ludwig, WD ;
Matutes, E ;
Orfao, A ;
Lanza, F ;
van't Veer, M .
LEUKEMIA, 2004, 18 (03) :394-400
[10]   Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts [J].
Blau, Olga ;
Baldus, Claudia Dorothea ;
Hofmann, Wolf-Karsten ;
Thiel, Gundula ;
Nolte, Florian ;
Burmeister, Thomas ;
Tuerkmen, Seval ;
Benlasfer, Ouidad ;
Schuemann, Elke ;
Sindram, Annette ;
Molkentin, Mara ;
Mundlos, Stefan ;
Keilholz, Ulrich ;
Thiel, Eckhard ;
Blau, Igor Wolfgang .
BLOOD, 2011, 118 (20) :5583-5592
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