Protection from respiratory virus infections can be mediated by antigen-specific CD4+ T cells that persist in the lungs

被引:241
作者
Hogan, RJ [1 ]
Zhong, WM [1 ]
Usherwood, EJ [1 ]
Cookenham, T [1 ]
Roberts, AD [1 ]
Woodland, DL [1 ]
机构
[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA
关键词
immunologic memory; immunity; mucosal; paramyxovirus; CD4(+) T lymphocytes;
D O I
10.1084/jem.193.8.981
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although CD4(+) T cells have been shown to mediate protective cellular immunity against respiratory virus infections, the underlying mechanisms are poorly understood. For example, although phenotypically distinct populations of memory CD4(+) T cells have been identified in different secondary lymphoid tissues, it is not known which subpopulations mediate protective cellular immunity. In this report, we demonstrate that virus-specific CD4(+) T cells persist in the lung tissues and airways for several months after Sendai virus infection of C57BL/6 mice. A large proportion of these cells possess a highly activated phenotype (CD44(hi), CD62L(lo), CD43(hi), and CD25(hi)) and express immediate effector function as indicated by the production of interferon gamma after a 5-h restimulation in vitro. Furthermore, intratracheal adoptive transfer of lung memory cells into beta (2)m-deficient mice demonstrated that lung-resident virus-specific CD4(+) T cells mediated a substantial degree of protection against secondary virus infection. Taken together, these data demonstrate that activated memory CD4(+) T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity.
引用
收藏
页码:981 / 986
页数:6
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