Phenotypic heterogeneity of microbial populations under nutrient limitation

被引：20

作者：

Gasperotti, Ana ^{[1
]}

Brameyer, Sophie ^{[1
]}

Fabiani, Florian ^{[1
]}

Jung, Kirsten ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Microbiol, D-82152 Martinsried, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 62卷 / 62期

关键词：

GENE-EXPRESSION; NETWORK; SYSTEM; TIME;

D O I：

10.1016/j.copbio.2019.09.016

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic heterogeneity is a phenomenon in which genetically identical individuals have different characteristics. This behavior can also be found in bacteria, even if they grow as monospecies in well-mixed environments such as bioreactors. Here it is discussed how phenotypic heterogeneity is generated by internal factors and how it is promoted under nutrient-limited growth conditions. A better understanding of the molecular levels that control phenotypic heterogeneity could improve biotechnological production processes.

引用

页码：160 / 167

页数：8

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