Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats

被引：3

作者：

Brindha, E. ^{[1
]}

Rajasekapandiyan, M. ^{[2
]}

机构：

[1] Muthaymmal Coll Arts & Sci, Dept Biotechnol, Rasipuram 637408, Tamil Nadu, India

[2] Arignar Anna Govt Arts & Sci Coll, Dept Zool, Villupuram, Tamil Nadu, India

来源：

TOXICOLOGY MECHANISMS AND METHODS | 2015年 / 25卷 / 02期

关键词：

Isoproterenol; lysosomal enzymes; myocardial infarction; phytic acid; HEART; NECROSIS;

D O I：

10.3109/15376516.2014.1003421

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for two days showed a significant increase in the activities of lysosomal enzymes (glucuronidase, N-acetyl glucosaminidase, galactosidase, cathepsin-B and cathepsin-D) were increased significantly in serum and the heart of ISO-induced rats, but the activities of glucuronidase and cathepsin-D were decreased significantly in the lysosomal fraction of the heart. Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats. Thus, phytic acid possesses a cardioprotective effect in ISO-induced MI in rats.

引用

页码：150 / 154

页数：5

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