Anti-p200 pemphigoid: clinical, diagnostic and therapeutic aspects

被引：1

作者：

Drerup, Katharina Antonia ^{[1
]}

Wehkamp, Ulrike ^{[1
]}

机构：

[1] Campus Kiel, Universitatsklinikum Schleswig, Rosalind-Franklin-Str. 7, DE-24105 Kiel, Germany

来源：

HAUTARZT | 2020年 / 71卷 / 02期

关键词：

Autoimmune bullous disease; Immunoblotting; Enzyme-linked immunosorbent assay; Dapsone; Immunoglobulin G autoantibodies;

D O I：

10.1007/s00105-019-04478-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Anti-p200 pemphigoid is a rare autoimmune blistering dermatosis. The clinical course is heterogeneous. Typically, immunoglobulin G (IgG) antibodies are found on the floor of salt-split skin, which differentiates p200 pemphigoid from bullous pemphigoid. It is necessary to perform immunoblotting and enzyme-linked immunosorbent assays (ELISA) to confirm the diagnosis. Small amounts of dapsone are often sufficient for disease control. The clinical and diagnostic characteristics of anti-p200 pemphigoid and the principles of treatment are presented exemplified by two case reports.

引用

页码：130 / 133

页数：4

共 8 条

[1] Clinical and immunological features and outcome of anti-p200 pemphigoid [J].

Commin, M. -H. ;

Schmidt, E. ;

Duvert-Lehembre, S. ;

Lasek, A. ;

Morice, C. ;

Estival, J. -L. ;

Debarbieux, S. ;

Rigal, E. ;

Pauwels, C. ;

De Quatrebarbes, J. ;

Roussel, A. ;

Goujon, E. ;

Stoebner, P. -E. ;

Jouen, F. ;

Joly, P. .

BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (04) :776-781

[2] Anti-laminin gamma-1 pemphigoid [J].

Dainichi, Teruki ;

Kurono, Sadamu ;

Ohyama, Bungo ;

Ishii, Norito ;

Sanzen, Noriko ;

Hayashi, Maria ;

Shimono, Chisei ;

Taniguchi, Yukimasa ;

Koga, Hiroshi ;

Karashima, Tadashi ;

Yasumoto, Shinichiro ;

Zillikens, Detlef ;

Sekiguchi, Kiyotoshi ;

Hashimoto, Takashi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2800-2805

[3] S2k Guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid [J].

Eming, Ruediger ;

Sticherling, Michael ;

Hofmann, Silke C. ;

Hunzelmann, Nicolas ;

Kern, Johannes S. ;

Kramer, Harald ;

Pfeiffer, Christiane ;

Schuster, Volker ;

Zillikens, Detlef ;

Goebeler, Matthias ;

Hertl, Michael ;

Nast, Alexander ;

Orzechowski, Hans-Dieter ;

Sardy, Miklos ;

Schmidt, Enno ;

Sitaru, Cassian ;

Sporbeck, Birte ;

Worm, Margitta .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2015, 13 (08) :833-845

[4] Anti-p200 pemphigoid [J].

Goletz, Stephanie ;

Hashimoto, Takashi ;

Zillikens, Detlef ;

Schmidt, Enno .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (01) :185-191

[5] Anti-p200 pemphigoid [J].

Holtsche, M. M. ;

Goletz, S. ;

Zillikens, D. .

HAUTARZT, 2019, 70 (04) :271-276

[6] Anti-p200 pemphigoid: Remission under mycophenolate mofetil (Cellcept®) [J].

Raffin, D. ;

Delaplace, M. ;

Roussel, A. ;

Esteve, E. .

ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2013, 140 (12) :784-787

[7] Histopathology of anti-p200 pemphigoid [J].

Rose, Christian ;

Weyers, Wolfgang ;

Denisjuk, Natalja ;

Hillen, Uwe ;

Zillikens, Detlef ;

Shimanovich, Iakov .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2007, 29 (02) :119-124

[8] A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone [J].

Zillikens, D ;

Kawahara, Y ;

Ishiko, A ;

Shimizu, H ;

Mayer, J ;

Rank, CV ;

Liu, Z ;

Giudice, GJ ;

Tran, HH ;

Marinkovich, MP ;

Brocker, EB ;

Hashimoto, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (03) :465-470

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