Transcriptional regulation of T cell metabolism and metabolic control of T cell gene expression

被引:1
作者
Veliz, Kimberly [1 ]
Beier, Ulf H. [2 ,3 ,4 ]
机构
[1] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Div Nephrol, Philadelphia, PA 19104 USA
[3] Univ Penn, Philadelphia, PA 19104 USA
[4] Janssen Res & Dev, Spring House, PA 19477 USA
关键词
ENERGY-METABOLISM; LACTIC-ACID; GLYCOLYSIS; GLUCOSE; METHYLATION; EPIGENETICS; CHECKPOINT; DYNAMICS; LACTATE; FOXP3;
D O I
10.1016/j.gde.2021.06.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
T cells undergo activation, maturation, and differentiation in which they can substantially transform and restructure. This includes metabolic adaptations which have been well recognized to be specific for T cell subsets. T cell subset specific metabolism is thought to reflect different bioenergetic requirements as well as adaptations to environmental conditions in which the T cells operate. The metabolic changes that occur in T cells are orchestrated by signaling cascades that lead to rapid post-translational changes and through transcription factors which facilitate more long-term adaptations. In addition, metabolites produced within T cells or taken up from the environment can influence gene expression by altering chromatin accessibility or the effectiveness of transcription factors through post-translational modifications, and thus act as transcription regulators in their own right.
引用
收藏
页码:83 / 88
页数:6
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