Anticancer agents interacting with membrane glucose transporters

被引：2
|
作者：
Granchi, C. [1 ]
Fortunato, S. [1 ]
Minutolo, F. [1 ]
机构：
[1] Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy
来源：
MEDCHEMCOMM | 2016年 / 7卷 / 09期
基金：
美国国家卫生研究院;
关键词：
PHLORETIN-INDUCED APOPTOSIS; GLUT1 HEXOSE TRANSPORTER; BREAST-CANCER CELLS; CYTOCHALASIN-B; LUNG-CANCER; IN-VITRO; PHASE-I; BIOLOGICAL EVALUATION; SILYBIN-PHYTOSOME; CURCUMIN ANALOG;
D O I：
10.1039/c6md00287k
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The altered metabolism observed in cancer cells generally consists of increased glucose uptake and glycolytic activity. This is associated with an overexpression of glucose transporter proteins (GLUTs), which facilitate glucose uptake across the plasma membrane and play a crucial role in the survival of cancer cells. Therefore, GLUTs are considered as suitable targets for treatment of cancer. Herein we review some of the most relevant GLUT inhibitors that have been recently developed as prospective anticancer agents.
引用
收藏
页码：1716 / 1729
页数：14
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