Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertension

被引:9
作者
Burke, Sandra L. [1 ]
Evans, Roger G. [2 ]
Head, Geoffrey A. [1 ,3 ]
机构
[1] Baker IDI Heart & Diabet Inst, Neuropharmacol Lab, Melbourne, Vic 8008, Australia
[2] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia
[3] Monash Univ, Dept Pharmacol, Clayton, Vic 3168, Australia
基金
英国医学研究理事会;
关键词
blood pressure; rabbits; renal function; renal sympathetic nerve activity; renin; renovascular hypertension; rilmenidine; sympathetic nervous system; IMIDAZOLINE-PREFERRING RECEPTORS; NERVOUS-SYSTEM; CONSCIOUS DOGS; BLOOD-FLOW; RILMENIDINE; MOXONIDINE; RABBITS; NATRIURESIS; ARTERIAL; DISEASE;
D O I
10.1097/HJH.0b013e3283449529
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective Treatment of renovascular hypertension with drugs that directly target the renin-angiotensin system may compromise glomerular filtration and renal excretory function, leading to renal failure. Centrally acting sympathoinhibitory agents also inhibit the renin-angiotensin system, so we determined whether this treatment modality alters renal excretory function in rabbits with renovascular hypertension. Methods Rabbits were equipped with bilateral renal artery flow probes and a renal nerve electrode. Hypertension was induced with a renal artery clip (2K1C) or rabbits were sham-clipped. After 2 weeks, a subcutaneous minipump was implanted to deliver rilmenidine (2.5 mg/kg per day) or vehicle for 3 weeks. Haemodynamic variables and renal function were studied under control conditions and during intravenous infusion of isotonic saline (154 mmol/l NaCl) at increasing rates of 4, 12 and 36 ml/kg per hour. Results Mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were greater in 2K1C rabbits than sham-clipped rabbits, but total urine flow, sodium excretion and glomerular filtration rate were similar in the two groups. In 2K1C rabbits, rilmenidine reduced MAP to close to control levels and reduced RSNA (40%), but did not significantly alter basal renal blood flow, glomerular filtration rate, urine flow or sodium excretion. The natriuretic response to isotonic saline load in 2K1C rabbits was not significantly altered by rilmenidine. Conclusion These observations show that chronic treatment of rabbits with renal artery stenosis with a centrally acting sympathoinhibitory agent, despite normalizing MAP, does not compromise renal excretory function. Thus, this treatment modality may be particularly useful in renovascular hypertension. J Hypertens 29: 945-952 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:945 / 952
页数:8
相关论文
共 50 条
[31]   Effect of endovascular treatment on nitric oxide and renal function in Takayasu's arteritis with renovascular hypertension [J].
Parildar, Z ;
Gulter, C ;
Parildar, M ;
Oran, I ;
Erdener, D ;
Memis, A .
KIDNEY & BLOOD PRESSURE RESEARCH, 2002, 25 (02) :91-96
[32]   Value of the Filtration Fraction Assessed by Dynamic 99mTc-Diethylenetriaminepentaacetic Acid Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition for the Diagnosis of Renovascular Hypertension [J].
Shin, Eonwoo ;
Sung, Changhwan ;
Son, Hye Joo ;
Lee, Dong Yun ;
Chae, Sun Young ;
Moon, Dae Hyuk .
NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 53 (04) :270-277
[33]   Daily consumption of monosodium glutamate pronounced hypertension and altered renal excretory function in normotensive and hypertensive rats [J].
Thongsepee, Nattaya ;
Martviset, Pongsakorn ;
Chantree, Pathanin ;
Sornchuer, Phornphan ;
Sangpairoj, Kant ;
Prathaphan, Parisa ;
Ruangtong, Jittiporn ;
Hiranyachattada, Siriphun .
HELIYON, 2022, 8 (10)
[34]   Renal function in gravidas with chronic hypertension with and without superimposed preeclampsia [J].
Nisell, H ;
Kublickas, M ;
Lunell, NO ;
Pettersson, E .
HYPERTENSION IN PREGNANCY, 1996, 15 (01) :127-134
[35]   Hypertension and VEGF (Vascular Endothelial Growth Factor) Receptor Tyrosine Kinase Inhibition Effects on Renal Function [J].
Boursiquot, Brian C. ;
Zabor, Emily C. ;
Glezerman, Ilya G. ;
Jaimes, Edgar A. .
HYPERTENSION, 2017, 70 (03) :552-558
[36]   Transplantation of bone marrow-derived MSCs improves renal function and Na++K+-ATPase activity in rats with renovascular hypertension [J].
Lira, Rafaelle ;
Oliveira, Mariana ;
Martins, Marcela ;
Silva, Caroline ;
Carvalho, Simone ;
Stumbo, Ana Carolina ;
Cortez, Erika ;
Verdoorn, Karine ;
Einicker-Lamas, Marcelo ;
Thole, Alessandra ;
de Carvalho, Lais .
CELL AND TISSUE RESEARCH, 2017, 369 (02) :287-301
[37]   Effects of Losartan on renal function in patients with essential hypertension [J].
Fauvel, JP ;
Velon, S ;
Berra, N ;
Pozet, N ;
Madonna, O ;
Zech, P ;
Laville, M .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 28 (02) :259-263
[38]   Differential effects of renal denervation on arterial baroreceptor function in Goldblatt hypertension model [J].
Lincevicius, Gisele S. ;
Shimoura, Caroline G. ;
Nishi, Erika E. ;
Oliveira, Tales ;
Cespedes, Juliana G. ;
Bergamaschi, Cassia T. ;
Campos, Ruy R. .
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2017, 208 :43-50
[39]   Renal effects chronic nitric oxide synthesis inhibition in cirrhotic rats with ascites [J].
Ortiz, MC ;
Fortepiani, LA ;
Martínez-Salgado, C ;
Eleno, N ;
Atucha, NM ;
López-Novoa, JM ;
García-Estañ, J .
NEFROLOGIA, 2001, 21 (06) :556-564
[40]   Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension [J].
Kashyap, Sonu ;
Warner, Gina M. ;
Hartono, Stella P. ;
Boyilla, Rajendra ;
Knudsen, Bruce E. ;
Zubair, Adeel S. ;
Lien, Karen ;
Nath, Karl A. ;
Textor, Stephen C. ;
Lerman, Lilach O. ;
Grande, Joseph P. .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2016, 310 (05) :F372-F384