IL-17 in Renal Immunity and Autoimmunity

被引：24
|
作者：
Biswas, Partha S. [1 ]
机构：
[1] Univ Pittsburgh, Div Rheumatol & Clin Immunol, S725 Biol South Tower,3500 Terrace Ave, Pittsburgh, PA 15261 USA
来源：
JOURNAL OF IMMUNOLOGY | 2018年 / 201卷 / 11期
基金：
美国国家卫生研究院;
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELLS; TH17; CELLS; HOST-DEFENSE; CRESCENTIC GLOMERULONEPHRITIS; INTERLEUKIN; 17; I INTERFERON; DISEASE; INFLAMMATION; IL-23;
D O I：
10.4049/jimmunol.1801042
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The kidney is an organ particularly susceptible to damage caused by infections and autoimmune conditions. Renal inflammation confers protection against microbial infections. However, if unchecked, unresolved inflammation may lead to kidney damage. Although proinflammatory cytokine IL-17 is required for immunity against extracellular pathogens, dysregulated IL-17 response is also linked to autoimmunity. In this review, we will discuss the current knowledge of IL-17 activity in the kidney in context to renal immunity and autoimmunity and raise the intriguing question to what extent neutralization of IL-17 is beneficial or harmful to renal inflammation.
引用
收藏
页码：3153 / 3159
页数：7
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