The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review

被引：0
作者：
Kim, Hye Young
Yoo, Young Hyun [1 ]
机构：
[1] Dong A Univ, Dept Anat & Cell Biol, Dept Translat Biomed Sci, Coll Med, Busan 49201, South Korea
来源：
BIOMEDICINES | 2022年 / 10卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
NAFLD; STAMP2; metalloreductase; iron homeostasis; 6-TRANSMEMBRANE EPITHELIAL ANTIGEN; NECROSIS-FACTOR-ALPHA; PROSTATE; 4; STEAP4; ADIPOSE-RELATED PROTEIN; TYPE-2; DIABETES-MELLITUS; 6 TRANSMEMBRANE PROTEIN; METABOLIC SYNDROME; IRON OVERLOAD; INSULIN-RESISTANCE; POSITIVE REGULATOR;
D O I：
10.3390/biomedicines10092082
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nonalcoholic fatty liver disease (NAFLD) is a major health issue. NAFLD can progress from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). NASH can progress to cirrhosis or hepatocellular carcinoma. Unfortunately, there is no currently approved pharmacologic therapy for NAFLD patients. The six transmembrane protein of prostate 2 (STAMP2), a metalloreductase involved in iron and copper homeostasis, is well known for its critical role in the coordination of glucose/lipid metabolism and inflammation in metabolic tissues. We previously demonstrated that hepatic STAMP2 could be a suitable therapeutic target for NAFLD. In this review, we discuss the emerging role of STAMP2 in the dysregulation of iron metabolism events leading to NAFLD and suggest therapeutic strategies targeting STAMP2.
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页数：14
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