Single-cell reconstruction of the early maternal-fetal interface in humans

被引：1562

作者：

Vento-Tormo, Roser ^{[1
,2
]}

Efremova, Mirjana ^{[1
]}

Botting, Rachel A. ^{[3
]}

Turco, Margherita Y. ^{[2
,4
,5
]}

Vento-Termo, Miquel ^{[6
]}

Meyer, Kerstin B. ^{[1
]}

Park, Jong-Eun ^{[1
]}

Stephenson, Emily ^{[3
]}

Polanski, Krzysztof ^{[1
]}

Goncalves, Angela ^{[1
,7
]}

Gardner, Lucy ^{[2
,4
]}

Holmqvist, Staffan ^{[8
]}

Henriksson, Johan ^{[1
]}

Zou, Angela ^{[1
]}

Sharkey, Andrew M. ^{[2
,4
]}

Millar, Ben ^{[3
]}

Innes, Barbara ^{[3
]}

Wood, Laura ^{[1
]}

Wilbrey-Clark, Anna ^{[1
]}

Payne, Rebecca P. ^{[3
]}

Ivarsson, Martin A. ^{[4
]}

Lisgo, Steve ^{[9
]}

Filby, Andrew ^{[3
]}

Rowitch, David H. ^{[8
]}

Bulmer, Judith N. ^{[3
]}

Wright, Gavin J. ^{[1
]}

Stubbington, Michael J. T. ^{[1
]}

Haniffa, Muzlifah ^{[1
,3
,10
,11
]}

Moffett, Ashley ^{[2
,4
]}

Teichmann, Sarah A. ^{[1
,12
,13
]}

机构：

[1] Wellcome Sanger Inst, Cambridge, England

[2] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England

[3] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

[4] Univ Cambridge, Dept Pathol, Cambridge, England

[5] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England

[6] YDEVS Software Dev, Valencia, Spain

[7] German Canc Res Ctr, Heidelberg, Germany

[8] Univ Cambridge, Wellcome MRC Cambridge Stem Cell Inst, Dept Paediat, Cambridge, England

[9] Newcastle Univ, Inst Genet Med, Human Dev Biol Resource, Newcastle Upon Tyne, Tyne & Wear, England

[10] Newcastle Hosp NHS Fdn Trust, Dept Dermatol, Newcastle Upon Tyne, Tyne & Wear, England

[11] Newcastle Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England

[12] Univ Cambridge, Cavendish Lab, Theory Condensed Matter Grp, Cambridge, England

[13] EBI, European Mol Biol Lab, Cambridge, England

来源：

NATURE | 2018年 / 563卷 / 7731期

基金：

英国惠康基金;

关键词：

STIMULATING FACTOR-I; UTERINE NK CELLS; RNA-SEQ; HUMAN-ENDOMETRIUM; GENE-EXPRESSION; HUMAN PLACENTA; REVEALS; TRANSCRIPTOMICS; 1ST-TRIMESTER; LYMPHOCYTES;

D O I：

10.1038/s41586-018-0698-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. The cellular composition of human decidua reveals subsets of perivascolar and stromal cells that are located in distinct decidual layers. There are three major subsets of decidual natural killer cells that have distinctive immunomodulatory and chemokine profiles. We develop a repository of ligand-receptor complexes and a statistical tool to predict the cell-type specificity of cell-cell communication via these molecular interactions. Our data identify many regulatory interactions that prevent harmful innate or adaptive immune responses in this environment. Our single-cell atlas of the maternal-fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success.

引用

页码：347 / +

页数：26

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