Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis

被引：59

作者：

Hirotani, Makoto

Niino, Masaaki ^{[1
]}

Fukazawa, Toshiyuki ^{[2
]}

Kikuchi, Seiji ^{[3
]}

Yabe, Ichiro

Hamada, Shinsuke ^{[4
]}

Tajima, Yasutaka ^{[5
]}

Sasaki, Hidenao

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Sapporo Neurol Clin, Sapporo, Hokkaido, Japan

[3] Sapporo Minami Natl Hosp, Dept Neurol, Sapporo, Hokkaido, Japan

[4] Hokuyukai Neurol Hosp, Sapporo, Hokkaido, Japan

[5] Sapporo City Gen Hosp, Dept Neurol, Sapporo, Hokkaido, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 221卷 / 1-2期

关键词：

MS; TLR9; CpG DNA; Immunoregulation; DENDRITIC CELLS; T-CELLS; AUTOIMMUNE; MEMORY; TLR9;

D O I：

10.1016/j.jneuroim.2010.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：95 / 100

页数：6

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