Melatonin in children with autistic spectrum disorders: recent and practical data

被引：34

作者：

Doyen, C. ^{[1
]}

Mighiu, D. ^{[1
]}

Kaye, K. ^{[1
]}

Colineaux, C. ^{[1
]}

Beaumanoir, C. ^{[2
]}

Mouraeff, Y. ^{[2
]}

Rieu, C. ^{[2
]}

Paubel, P. ^{[2
]}

Contejean, Y. ^{[1
]}

机构：

[1] St Anne Hosp, Dept Child & Adolescent Psychopathol, F-75014 Paris, France

[2] St Anne Hosp, Dept Pharm & Sterilizat, F-75014 Paris, France

来源：

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | 2011年 / 20卷 / 05期

关键词：

Melatonin; Autism; Childhood; Sleep; Disorders; CONTROLLED-RELEASE MELATONIN; SLEEP DISORDERS; ALTERNATIVE MEDICINE; CONTROLLED-TRIAL; RETT-SYNDROME; COMPLEMENTARY; INSOMNIA; ADULTS; SERUM;

D O I：

10.1007/s00787-011-0162-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Over the last 20 years, melatonin, a pineal hormone synthesized from serotonin, has been implicated in various studies on the autism spectrum disorder (ASD) and altered melatonin levels were detected in subgroups of subjects with ASD. Its effect on sleep disturbances got the attention of clinicians and several investigations were carried out to determine the usefulness and safety of melatonin administration in this disorder. Hypotheses were also raised regarding the possibility that the dysfunctional synthesis and secretion of melatonin detected in subgroups of subjects with ASD may increase the risk as well the severity of ASD. The purpose of this paper is to review our pharmacokinetic knowledge on melatonin and present results from recent studies on sleep disorders in autism, their treatment with melatonin and the impact of melatonin prescription in children with ASD evaluated in a Diagnostic Center for Autism Spectrum Disorder in Paris, France.

引用

页码：231 / 239

页数：9

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