Antineoplastic and cytogenetic effects of platinum(II) and palladium(II) complexes with pyridine-2-carboxyaldehyde-thiosemicarbazone

被引：51
|
作者：
Kovala-Demertzi, D [1 ]
Demertzis, MA
Varagi, V
Papageorgiou, A
Mourelatos, D
Mioglou, E
Iakovidou, Z
Kotsis, A
机构：
[1] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece
[2] Aristotelian Univ Salonika, Anticanc Inst, Lab Expt Chemotherapy Theagen, GR-54006 Salonika, Greece
[3] Aristotelian Univ Salonika, Sch Med, Dept Biol & Genet, GR-54006 Salonika, Greece
来源：
CHEMOTHERAPY | 1998年 / 44卷 / 06期
关键词：
sister chromatid exchanges; cell kinetics; platinum(II) and palladium(II) complexes; pyridine-2-carboxyaldehyde thiosemicarbazone; antileukemic activity;
D O I：
10.1159/000007154
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of six novel complexes of Pt(II) and Pd(II) with pyridine-2-carboxyaldehyde thiosemicarbazone (HPyTsc) on sister chromatid exchange rate and human lymphocyte proliferation kinetic was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing cytogenetic and antineoplastic effects are the complexes [Pd(PyTsc)(2)] and [Pt(PyTsc)(2)]. Next in order of magnitude in inducing antineoplastic and cytogenetic effects is the compound [Pt(HPyTsc)(2)]Cl-2 while the rest, i.e. [Pd(PyTsc)Cl], HPyTsc, [Pd(HPyTsc)(2)]Cl-2, and [Pt(PyTsc)Cl], show marginal cytogenetic and antineoplastic effects.
引用
收藏
页码：421 / 426
页数：6
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