Immunotherapy and radiation therapy for gastrointestinal malignancies: hope or hype?

被引：2

作者：

Badiyan, Shahed ^{[1
]}

Kaiser, Adeel ^{[2
]}

Eastman, Bory ^{[3
]}

Forsthoefel, Matthew ^{[4
]}

Zeng, Jing ^{[3
]}

Unger, Keith ^{[4
]}

Chuong, Michael ^{[5
]}

机构：

[1] Washington Univ, Sch Med St Louis, St Louis, MO 63110 USA

[2] Univ Maryland, Med Ctr, Baltimore, MD 21201 USA

[3] Univ Washington, Med Ctr, Seattle, WA 98195 USA

[4] Georgetown Univ Hosp, Dept Radiat Oncol, Washington, DC 20007 USA

[5] Miami Canc Inst, Miami, FL USA

来源：

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY | 2020年 / 5卷

关键词：

Immunotherapy; radiation therapy; cancer; ACTIVE SPECIFIC IMMUNOTHERAPY; INDUCED KILLER-CELLS; PHASE-III TRIAL; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; ADJUVANT IMMUNOTHERAPY; ESOPHAGEAL CANCER; CTLA-4; BLOCKADE; LOCAL RADIATION;

D O I：

10.21037/tgh.2019.10.07

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immunotherapy represents the newest pillar in cancer care. Although there are increasing data showing the efficacy of immunotherapy there is a spectrum of response across unselected populations of cancer patients. In fact, response rates can be poor even among patients with immunogenic tumors for reasons that remain poorly understood. A promising clinical strategy to improve outcomes, which is supported by an abundance of preclinical data, is combining immunotherapy with radiation therapy. Here we review the existing evidence and future directions for combining immunotherapy and radiation therapy for patients with gastrointestinal cancers.

引用

页数：12

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