Human-brain ferritin studied by muon spin rotation: a pilot study

被引：13

作者：

Bossoni, Lucia ^{[1
]}

Moursel, Laure Grand ^{[2
,3
]}

Bulk, Marjolein ^{[2
,3
,4
]}

Simon, Brecht G. ^{[1
]}

Webb, Andrew ^{[3
]}

van der Weerd, Louise ^{[2
,3
]}

Huber, Martina ^{[1
]}

Carretta, Pietro ^{[5
]}

Lascialfari, Alessandro ^{[6
]}

Oosterkamp, Tjerk H. ^{[1
]}

机构：

[1] Leiden Univ, Huygens Kamerlingh Onnes Lab, NL-2333 CA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands

[4] Percuros BV, Leiden, Netherlands

[5] Pavia Univ, Dept Phys, Pavia, Italy

[6] Univ Milan, Dipartimento Fis, Milan, Italy

来源：

JOURNAL OF PHYSICS-CONDENSED MATTER | 2017年 / 29卷 / 41期

基金：

欧洲研究理事会;

关键词：

muon spin rotation; nanomagnetism; Alzheimer's disease; ferritin; ELECTRON MAGNETIC-RESONANCE; ALZHEIMERS-DISEASE; HUMAN-LIVER; IRON; RELAXATION; NANOPARTICLES; CORES; FERRIHYDRITE; RELAXOMETRY; HYSTERESIS;

D O I：

10.1088/1361-648X/aa80b3

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

Muon spin rotation is employed to investigate the spin dynamics of ferritin proteins isolated from the brain of an Alzheimer's disease (AD) patient and of a healthy control, using a sample of horse-spleen ferritin as a reference. A model based on the Neel theory of superparamagnetism is developed in order to interpret the spin relaxation rate of the muons stopped by the core of the protein. Using this model, our preliminary observations show that ferritins from the healthy control are filled with a mineral compatible with ferrihydrite, while ferritins from the AD patient contain a crystalline phase with a larger magnetocrystalline anisotropy, possibly compatible with magnetite or maghemite.

引用

页数：11

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