Surface Adsorption of the Cancer Biomarker Lysophosphatidic Acid in Serum Studied by Acoustic Wave Biosensor

被引：2

作者：

de la Franier, Brian ^{[1
]}

Thompson, Michael ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

来源：

MATERIALS | 2021年 / 14卷 / 15期

关键词：

lysophosphatidic acid; surface-modified gold; acoustic wave biosensor; non-specific adsorption; ANTIFOULING ORGANOSILANE ADLAYERS; POTENTIAL BIOMARKER; HYDRATION; OVARIAN; THROMBOGENESIS; PREVENTION; DYNAMICS; BLOOD;

D O I：

10.3390/ma14154158

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The thickness shear mode acoustic wave device is of interest for the sensing of biomarkers for diseases in various biological fluids, but suffers from the issue of non-specific adsorption of compounds other than those of interest to the electrode surface, thus affecting the device's output. The aim of this present study was to determine the level of non-specific adsorption on gold electrodes from serum samples with added ovarian cancer biomarker lysophosphatidic acid in the presence of a surface anti-fouling layer. The latter was an oligoethylene molecule with thiol group for attachment to the electrode surface. It was found that the anti-fouling layer had a minimal effect on the level of both adsorption of components from serum and the marker. This result stands in sharp contrast to the analogous monolayer employed for anti-fouling reduction on silica.

引用

页数：8

共 26 条

[1] Critical role of surface hydration on the dynamics of serum adsorption studied with monoethylene glycol adlayers on gold [J].

Avci, Ceren ;

Sheikh, Sonia ;

Blaszykowski, Christophe ;

Thompson, Michael .

CHEMICAL COMMUNICATIONS, 2013, 49 (05) :466-468

[2] Surface chemistry to minimize fouling from blood-based fluids [J].

Blaszykowski, Christophe ;

Sheikh, Sonia ;

Thompson, Michael .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (17) :5599-5612

[3] Human serum albumin corona on functionalized gold nanorods modulates doxorubicin loading and release [J].

Chakraborty, Debolina ;

Tripathi, Shivanshi ;

Ethiraj, K. R. ;

Chandrasekaran, N. ;

Mukherjee, Amitava .

NEW JOURNAL OF CHEMISTRY, 2018, 42 (20) :16555-16563

[4] Reduction of microbial adhesion on polyurethane by a sub-nanometer covalently-attached surface modifier [J].

De la Franier, Brian ;

Asker, Dalal ;

van den Berg, Desmond ;

Hatton, Benjamin ;

Thompson, Michael .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2021, 200

[5]

Fedorov K., 2020, RES PROG MAT SPEC IS, V2, P16, DOI [10.21926/rpm.2003019, DOI 10.21926/RPM.2003019]

[6] Prevention of surface-induced thrombogenesis on poly(vinyl chloride) [J].

Fedorov, Kiril ;

Jankowski, Alexander ;

Sheikh, Sonia ;

Blaszykowski, Christophe ;

Reheman, Adili ;

Romaschin, Alexander ;

Ni, Heyu ;

Thompson, Michael .

JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (44) :8623-8628

[7] Prevention of Thrombogenesis from Whole Human Blood on Plastic Polymer by Ultrathin Monoethylene Glycol Silane Adlayer [J].

Fedorov, Kiril ;

Blaszykowski, Christophe ;

Sheikh, Sonia ;

Reheman, Adili ;

Romaschin, Alexander ;

Ni, Heyu ;

Thompson, Michael .

LANGMUIR, 2014, 30 (11) :3217-3222

[8]

Gong Ping, 2007, V381, P59

[9]

Johannsmann D, 2015, SOFT BIOL MATTER, P1, DOI 10.1007/978-3-319-07836-6

[10] Low-Fouling Characteristics of Ultrathin Zwitterionic Cysteine SAMs [J].

Lin, Peter ;

Chuang, Tsung-Liang ;

Chen, Paul Z. ;

Lin, Chii-Wann ;

Gu, Frank X. .

LANGMUIR, 2019, 35 (05) :1756-1767

← 1 2 3 →