Drug Hypersensitivity Reactions

被引：28
作者：
Dykewicz, Mark S. [1 ]
Lam, Jason K. [1 ]
机构：
[1] St Louis Univ, Sch Med, Sect Allergy & Immunol,St Louis Univ Allergy & Im, Div Infect Dis Allergy & Immunol,Dept Internal Me, 1402 South Grand Blvd,Room M 157, St Louis, MO 63104 USA
来源：
MEDICAL CLINICS OF NORTH AMERICA | 2020年 / 104卷 / 01期
关键词：
Adverse drug reaction; Drug hypersensitivity reaction; Drug allergy; Drug rash; Skin testing; Graded challenge; Desensitization; ANGIOTENSIN RECEPTOR BLOCKERS; CROSS-REACTIVITY; MANAGEMENT; ALLERGY; ANGIOEDEMA; INHIBITORS; DIAGNOSIS; ASPIRIN; RISK;
D O I：
10.1016/j.mcna.2019.09.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Drug hypersensitivity reactions (DHRs) may be classified based on timing (immediate vs delayed), mechanisms, and pattern of clinical manifestations. Management may include selection of alternative, non-cross reactive agents, drug allergy testing, graded challenge and/or desensitization. Immediate skin testing only identifies risk for immediate-type allergic DHR and has a negative predictive value for only a limited number of drugs (eg, penicillin). Desensitization induces a temporary state of tolerance that is maintained only so long as the drug is continued. This article discusses special considerations about antibiotics, angiotensin-converting enzyme inhibitors, anesthetic agents, aspirin and nonsteroidal antiinflammatory drugs, radiocontrast media, and chemotherapeutic agents.
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收藏
页码：109 / +
页数：21
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