The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis

被引：25
作者：
Dou, Shu-Hui [1 ]
Cui, Yu [2 ]
Huang, Shu-Ming [1 ]
Zhang, Bo [1 ]
机构：
[1] Heilongjiang Univ Chinese Med, Inst Chinese Med, Dept Neurosci, Harbin, Peoples R China
[2] Hainan Univ, Coll Agr, Dept Vet Med, Haikou, Peoples R China
来源：
FRONTIERS IN HUMAN NEUROSCIENCE | 2022年 / 16卷
基金：
中国国家自然科学基金;
关键词：
brain-derived neurotrophic factor; TrkB; stroke; depression; anxiety; neurodegenerative disease; PARKINSONS-DISEASE; BDNF VAL66MET; HIPPOCAMPAL VOLUME; PROTEIN-LEVELS; MESSENGER-RNA; EXPRESSION; RECEPTOR; POLYMORPHISM; MEMORY; PLASTICITY;
D O I：
10.3389/fnhum.2022.924155
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer's disease, and Parkinson's disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.
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页数：8
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