The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis

被引：32

作者：

Dou, Shu-Hui ^{[1
]}

Cui, Yu ^{[2
]}

Huang, Shu-Ming ^{[1
]}

Zhang, Bo ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Inst Chinese Med, Dept Neurosci, Harbin, Peoples R China

[2] Hainan Univ, Coll Agr, Dept Vet Med, Haikou, Peoples R China

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2022年 / 16卷

基金：

中国国家自然科学基金;

关键词：

brain-derived neurotrophic factor; TrkB; stroke; depression; anxiety; neurodegenerative disease; PARKINSONS-DISEASE; BDNF VAL66MET; HIPPOCAMPAL VOLUME; PROTEIN-LEVELS; MESSENGER-RNA; EXPRESSION; RECEPTOR; POLYMORPHISM; MEMORY; PLASTICITY;

D O I：

10.3389/fnhum.2022.924155

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a variety of central nervous system (CNS) diseases (e.g., stroke, depression, anxiety, Alzheimer's disease, and Parkinson's disease). This suggests that BDNF may be involved in the pathogenesis of these diseases. Moreover, regulating BDNF signaling may represent a potential treatment for such diseases. With reference to recent research papers in related fields, this article reviews the production and regulation of BDNF in CNS and the role of BDNF signaling disorders in these diseases. A brief introduction of the clinical application status of BDNF is also provided.

引用

页数：8

共 75 条

[1] Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairment [J].

Altmann, Vivian ;

Schumacher-Schuh, Artur F. ;

Rieck, Mariana ;

Callegari-Jacques, Sidia M. ;

Rieder, Carlos R. M. ;

Hutz, Mara H. .

NEUROSCIENCE LETTERS, 2016, 615 :88-91

[2] BDNF-TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation and Psychiatric Disorders [J].

Andero, Rauel ;

Choi, Dennis C. ;

Ressler, Kerry J. .

MOLECULAR BASIS OF MEMORY, 2014, 122 :169-192

[3] 2020 Alzheimer's disease facts and figures [J].

不详 .

ALZHEIMERS & DEMENTIA, 2020, 16 (03) :391-460

[4] PURIFICATION OF A NEW NEUROTROPHIC FACTOR FROM MAMMALIAN BRAIN [J].

BARDE, YA ;

EDGAR, D ;

THOENEN, H .

EMBO JOURNAL, 1982, 1 (05) :549-553

[5] Increased Cerebellar Volume and BDNF Level Following Quadrato Motor Training [J].

Ben-Soussan, Tal Dotan ;

Piervincenzi, Claudia ;

Venditti, Sabrina ;

Verdone, Loredana ;

Caserta, Micaela ;

Carducci, Filippo .

SYNAPSE, 2015, 69 (01) :1-6

[6] Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington's Disease [J].

Benraiss, Abdellatif ;

Toner, Michael J. ;

Xu, Qiwu ;

Bruel-Jungerman, Elodie ;

Rogers, Eloise H. ;

Wang, Fushun ;

Economides, Aris N. ;

Davidson, Beverly L. ;

Kageyama, Ryoichiro ;

Nedergaard, Maiken ;

Goldman, Steven A. .

CELL STEM CELL, 2013, 12 (06) :787-799

[7] Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice [J].

Berry, Alessandra ;

Bellisario, Veronica ;

Capoccia, Sara ;

Tirassa, Paola ;

Calza, Arianna ;

Alleva, Enrico ;

Cirulli, Francesca .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (06) :762-772

[8]

Bhide PG, 1996, J NEUROSCI, V16, P5523

[9]

Borghesani PR, 2002, DEVELOPMENT, V129, P1435

[10] Imbalance of p75NTR/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies [J].

Brito, V. ;

Puigdellivol, M. ;

Giralt, A. ;

del Toro, D. ;

Alberch, J. ;

Gines, S. .

CELL DEATH & DISEASE, 2013, 4 :e595-e595

← 1 2 3 4 5 6 7 8 →