Effects of sympathetic inhibition on blood pressure and renal responses to central hypervolaemia in normal humans

The purpose of this study was to evaluate the effects of short-term sympathetic inhibition with clonidine on blood pressure and renal responses to central hypervolaemia induced by thermoneutral head-out water immersion. Eleven healthy subjects were randomly studied on two occasions. during a 1 h pre-immersion period. 2 h of water immersion and a 1 h post-immersion period. after either placebo or clonidine treatment. Clonidine caused a significant suppression of plasma adrenaline. plasma noradrenaline. urinary noradrenaline excretion and mean arterial blood pressure. Blood pressure remained constant during water immersion after both placebo and clonidine. compared with the respective pre-immersion control values. The suppression pattern of plasma catecholamines and urinary noradrenaline in response to water immersion during placebo was similar after clonidine treatment. Renal volume excretion was not affected by clonidine. In contrast. clonidine caused a significant attenuation of the immersion-induced stimulation of natriuresis (maximum -33+/-12%. P < 0.01. compared with placebo). These data indicate that the renal capacity to excrete sodium is impaired during moderate blood pressure reduction by short-term sympathetic inhibition with clonidine, whereas the regulation of arterial blood pressure in response to central hypervolaemia is maintained.