Covid-19 Vaccine Effectiveness and the Test-Negative Design

被引：104

作者：

Dean, Natalie E. ^{[1
]}

Hogan, Joseph W. ^{[2
]}

Schnitzer, Mireille E. ^{[3
,4
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

[2] Brown Univ, Sch Publ Hlth, Providence, RI USA

[3] Univ Montreal, Fac Pharm, Montreal, PQ, Canada

[4] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 15期

关键词：

D O I：

10.1056/NEJMe2113151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Observational studies are emerging as fundamental sources of information about vaccine effectiveness outside the controlled environment of randomized trials, and they are being used to generate evidence of effectiveness against outcomes that are underpowered in trials, such as hospitalization or intensive care unit (ICU) admission, or for narrow subgroups.(1) These studies can monitor the waning of vaccine effectiveness or measure the performance of vaccines against novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants when large randomized, controlled trials are not feasible.(2) Thompson et al.(3) now describe in the Journal the application of a retrospective test-negative design to estimate coronavirus . . .

引用

页码：1431 / 1433

页数：3

共 10 条

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