Covid-19 Vaccine Effectiveness and the Test-Negative Design

被引：113

作者：

Dean, Natalie E. ^{[1
]}

Hogan, Joseph W. ^{[2
]}

Schnitzer, Mireille E. ^{[3
,4
]}

机构：

[1] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

[2] Brown Univ, Sch Publ Hlth, Providence, RI USA

[3] Univ Montreal, Fac Pharm, Montreal, PQ, Canada

[4] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 15期

关键词：

D O I：

10.1056/NEJMe2113151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Observational studies are emerging as fundamental sources of information about vaccine effectiveness outside the controlled environment of randomized trials, and they are being used to generate evidence of effectiveness against outcomes that are underpowered in trials, such as hospitalization or intensive care unit (ICU) admission, or for narrow subgroups.(1) These studies can monitor the waning of vaccine effectiveness or measure the performance of vaccines against novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants when large randomized, controlled trials are not feasible.(2) Thompson et al.(3) now describe in the Journal the application of a retrospective test-negative design to estimate coronavirus . . .

引用

页码：1431 / 1433

页数：3

共 10 条

[1] The Use of Test-negative Controls to Monitor Vaccine Effectiveness A Systematic Review of Methodology [J].

Chua, Huiying ;

Feng, Shuo ;

Lewnard, Joseph A. ;

Sullivan, Sheena G. ;

Blyth, Christopher C. ;

Lipsitch, Marc ;

Cowling, Benjamin J. .

EPIDEMIOLOGY, 2020, 31 (01) :43-64

[2] Vaccine Effectiveness Studies in the Field [J].

Evans, Stephen J. W. ;

Jewell, Nicholas P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (07) :650-651

[3]

Greenland S, 1999, STAT SCI, V14, P29

[4] The test-negative design for estimating influenza vaccine effectiveness [J].

Jackson, Michael L. ;

Nelson, Jennifer C. .

VACCINE, 2013, 31 (17) :2165-2168

[5] Theoretical Framework for Retrospective Studies of the Effectiveness of SARS-CoV-2 Vaccines [J].

Lewnard, Joseph A. ;

Patel, Manish M. ;

Jewell, Nicholas P. ;

Verani, Jennifer R. ;

Kobayashi, Miwako ;

Tenforde, Mark W. ;

Dean, Natalie E. ;

Cowling, Benjamin J. ;

Lopman, Benjamin A. .

EPIDEMIOLOGY, 2021, 32 (04) :508-517

[6] VIEWPOINT: COVID-19 Understanding COVID-19 vaccine efficacy [J].

Lipsitch, Marc ;

Dean, Natalie E. .

SCIENCE, 2020, 370 (6518) :763-765

[7] Identifiability and Estimation Under the Test-negative Design With Population Controls With the Goal of Identifying Risk and Preventive Factors for SARS-CoV-2 Infection [J].

Schnitzer, Mireille E. ;

Harel, Daphna ;

Ho, Vikki ;

Koushik, Anita ;

Merckx, Joanna .

EPIDEMIOLOGY, 2021, 32 (05) :690-697

[8] Theoretical Basis of the Test-Negative Study Design for Assessment of Influenza Vaccine Effectiveness [J].

Sullivan, Sheena G. ;

Tchetgen, Eric J. Tchetgen ;

Cowling, Benjamin J. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2016, 184 (05) :345-353

[9] Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings [J].

Thompson, M. G. ;

Stenehjem, E. ;

Grannis, S. ;

Ball, S. W. ;

Naleway, A. L. ;

Ong, T. C. ;

DeSilva, M. B. ;

Natarajan, K. ;

Bozio, C. H. ;

Lewis, N. ;

Dascomb, K. ;

Dixon, B. E. ;

Birch, R. J. ;

Irving, S. A. ;

Rao, S. ;

Kharbanda, E. ;

Han, J. ;

Reynolds, S. ;

Goddard, K. ;

Grisel, N. ;

Fadel, W. F. ;

Levy, M. E. ;

Ferdinands, J. ;

Fireman, B. ;

Arndorfer, J. ;

Valvi, N. R. ;

Rowley, E. A. ;

Patel, P. ;

Zerbo, O. ;

Griggs, E. P. ;

Porter, R. M. ;

Demarco, M. ;

Blanton, L. ;

Steffens, A. ;

Zhuang, Y. ;

Olson, N. ;

Barron, M. ;

Shifflett, P. ;

Schrag, S. J. ;

Verani, J. R. ;

Fry, A. ;

Gaglani, M. ;

Azziz-Baumgartner, E. ;

Klein, N. P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (15) :1355-1371

[10] Test-Negative Designs Differences and Commonalities with Other Case-Control Studies with "Other Patient" Controls [J].

Vandenbroucke, Jan P. ;

Pearce, Neil .

EPIDEMIOLOGY, 2019, 30 (06) :838-844

← 1 →