Creating chemical diversity space by scaffold decoration of dihydropyrimidines

被引：43

作者：

Dallinger, D ^{[1
]}

Kappe, CO ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

PURE AND APPLIED CHEMISTRY | 2005年 / 77卷 / 01期

关键词：

D O I：

10.1351/pac200577010155

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The demand for diverse compound libraries for screening in drug discovery and materials science is the driving force behind the development of new technologies for rapid parallel and combinatorial synthesis. The focus of this article will be on the scaffold decoration of biologically active dihydropyrimidines (DHPMs) of the Biginelli type, exploring the diversity on all six positions around the scaffold. This opens up the generation of a very large number of analogs given the commercial availability of the building blocks that are used in the functionalization process.

引用

页码：155 / 161

页数：7

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