Regional Brain Activity in Functional Dyspepsia: A H215O-PET Study on the Role of Gastric Sensitivity and Abuse History

被引：69

作者：

Van Oudenhove, Lukas ^{[1
,2
]}

Vandenberghe, Joris ^{[1
]}

Dupont, Patrick ^{[3
,4
]}

Geeraerts, Brecht ^{[2
]}

Vos, Rita ^{[2
]}

Dirix, Stijn ^{[5
]}

Van Laere, Koen ^{[5
]}

Bormans, Guy ^{[6
]}

Vanderghinste, Dominique ^{[6
]}

Demyttenaere, Koen ^{[1
]}

Fischler, Benjamin ^{[1
]}

Tack, Jan ^{[2
]}

机构：

[1] Univ Leuven, Div Psychiat, Dept Neurosci, Univ Hosp Gasthuisberg, Louvain, Belgium

[2] Univ Leuven, Dept Pathophysiol, Div Gastroenterol, Univ Hosp Gasthuisberg, Louvain, Belgium

[3] Univ Leuven, Dept Neurosci, Expt Neurol Div, Lab Cognit Neurol,Univ Hosp Gasthuisberg, Louvain, Belgium

[4] Univ Leuven, Med Imaging Res Ctr, Univ Hosp Gasthuisberg, Louvain, Belgium

[5] Univ Leuven, Div Nucl Med, Dept Med Diagnost Sci, Univ Hosp Gasthuisberg, Louvain, Belgium

[6] Univ Leuven, Univ Hosp Gasthuisberg, Lab Radiopharmacy, Fac Pharmaceut Sci, Louvain, Belgium

来源：

GASTROENTEROLOGY | 2010年 / 139卷 / 01期

关键词：

Functional Dyspepsia; Gastric Hypersensitivity; Abuse; Brain; IRRITABLE-BOWEL-SYNDROME; CHILDHOOD ABUSE; VISCERAL PAIN; GASTROINTESTINAL DISORDERS; SENSORIMOTOR FUNCTION; FUNDIC DISTENSION; DEFAULT MODE; BLOOD-FLOW; RESPONSES; CORTEX;

D O I：

10.1053/j.gastro.2010.04.015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Differences in brain activity between health and functional dyspepsia (FD) have been reported; it is unclear whether this is influenced by gastric hypersensitivity or abuse history. Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD. METHODS: Abuse history was assessed using a validated self-report questionnaire. H(2)(15)O positron emission tomography was performed in 25 FD patients (13 hypersensitive and 8 abused) during 3 conditions, that is, no distension, gastric distension at discomfort threshold, and sham distension. Data were analyzed in SPM2. Region of interest analysis was used to confirm differences in prehypothesized regions. RESULTS: No association between hypersensitivity and abuse history was found. Gastric hypersensitivity was associated with significantly higher gastric sensation scores during baseline and sham. A condition-independent difference in ventral posterior cingulate activity was found between groups, as well as distension and sham-specific differences in brainstem and cingulate areas. Abuse history was associated with higher gastric sensation scores in all conditions and with differences in insular, prefrontal, and hippocampus/amygdala activity. CONCLUSIONS: Gastric sensitivity and abuse history independently influence gastric sensation as well as brain activity in FD.

引用

页码：36 / 47

页数：12

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