Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco

被引：0

作者：

El Baghdadi, J

Remus, N

Benslimane, A

El Annaz, H

Chentoufi, M

Abel, L

Schurr, E

机构：

[1] Inst Pasteur Maroc, Serv Genet Microbienne, Casablanca, Morocco

[2] Univ Paris 05, INSERM, Lab Genet Humaine Malad Infect, U550, Paris, France

[3] Fac Med, Ctr Immunol, Casablanca, Morocco

[4] Ctr Diagnost Specialise TB, Casablanca, Morocco

[5] Hop Gen Montreal, Ctr Resistance Hote, Montreal, PQ, Canada

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2003年 / 7卷 / 06期

关键词：

NRAMP1; tuberculosis; Morocco;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

It has been well established that the host genetic background is an important modulator of tuberculosis susceptibility. The NRAMP1 (alias SLC11A1) gene has been associated with tuberculosis susceptibility in several ethnic groups. Here we studied the association and linkage of NRAMP1 with tuberculosis in 116 nuclear families, comprising 211 affected offspring, from Casa-blanca, Morocco. All enrolled tuberculosis cases were culture-positive. No evidence was found of linkage or association of NRAMP1 with tuberculosis. These findings suggest heterogeneity in the genetic control of tuberculosis susceptibility.

引用

页码：599 / 602

页数：4

共 25 条

[1] Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-scope methods, in multipoint linkage analysis of affected-sibship data [J].