Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation

被引：117

作者：

Gao, Zheng-Run ^{[1
,2
]}

Chen, Wen-Zhen ^{[1
,2
]}

Liu, Ming-Zhe ^{[1
,2
]}

Chen, Xiao-Jun ^{[1
,2
]}

Wan, Li ^{[3
]}

Zhang, Xin-Yan ^{[1
,2
]}

Yuan, Lei ^{[1
,2
]}

Lin, Jun-Kai ^{[1
,2
]}

Wang, Meng ^{[1
,2
]}

Zhou, Li ^{[1
,2
]}

Xu, Xiao-Hong ^{[1
]}

Sun, Yan-Gang ^{[1
]}

机构：

[1] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China

[2] Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 2, State Key Specialty Pain Med, Dept Pain Management, Guangzhou, Guangdong, Peoples R China

来源：

NEURON | 2019年 / 101卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ROSTRAL VENTROMEDIAL MEDULLA; DORSAL-HORN NEURONS; SPINAL-CORD; PEPTIDERGIC ORGANIZATION; ELECTRICAL-STIMULATION; PAIN; BRAIN; ANALGESIA; CIRCUITS; RAT;

D O I：

10.1016/j.neuron.2018.11.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Uncontrollable itch-scratching cycles lead to serious skin damage in patients with chronic itch. However, the neural mechanism promoting the itch-scratching cycle remains elusive. Here, we report that tachykinin 1 (Tact)-expressing glutamatergic neurons in the lateral and ventrolateral periaqueductal gray (l/vlPAG) facilitate the itch-scratching cycle. We found that l/vlPAG neurons exhibited scratching-behavior-related neural activity and that itch-evoked scratching behavior was impaired after suppressing the activity of l/vlPAG neurons. Furthermore, we showed that the activity of Tac1-expressing glutamatergic neurons in the l/vlPAG was elevated during itch-induced scratching behavior and that ablating or suppressing the activity of these neurons decreased itch-induced scratching behavior. Importantly, activation of Tac1-expressing neurons induced robust spontaneous scratching and grooming behaviors. The scratching behavior evoked by Tac1-expressing neuron activation was suppressed by ablation of spinal neurons expressing gastrin-releasing peptide receptor (GRPR), the key relay neurons for itch. These results suggest that Tac1-expressing neurons in the l/vlPAG promote itch-scratching cycles.

引用

页码：45 / +

页数：24

共 74 条

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