Synthesis, chemical and biological investigations of new Ru(III) and Se(IV) complexes containing 1,3,5-triazine chelating derivatives

A series of vital complexes of [Se (L-n) (Cl)(x)]center dot yCl (where n = L-1, L-2, L-3 and L-4; x = 1, 2, or 3 and y = 1, 2, or 3) and [Ru (L-n) (Cl)(x) (H2O)(y)]zCl (where x = 2 or 3; y = 0,1 or 2 and z = 0 or 1) have been synthesized from the chemical reactions between ruthenium (III) or selenium (IV) salts and tri-substituted s-triazine derivatives (L-1 = N-2-(4-chlorophenyl)-N-4,N-6-di (pyrimidin-2-yl)-1,3,5-triazine-2,4,6-triamine; L-2 = N-2-(4-chlorophenyl)-N-4- (pyrimidin-2-yl)- N-6-(thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine; L-3 = 6-chloro-N-2-(pyrimidin-2-yl)-N-4-(1H-1,2,4-triazol-3-yl)-1,3,5-triazine-2,4-diamine and L-4 = 6-chloro-N-2-(4-chlorophenyl)-N-4-(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine). The structural was investigated using of elemental analyses, molar conductance, IR, UV-Vis, magnetic susceptibility, H-1, C-13 NMR spectra and thermal analyses. The surface morphology behaviors of selenium (IV) and ruthenium (111) complexes were studied based on scanning and transmittance electron microscopes. The crystalline nature of s-triazine complexes have been investigated using X-ray powder diffraction spectra. Spectral results were concluded that the ligand acts as a neutral bidentate for (L-1 and L-4) and tridentate for (L-2 and L-3), and coordinates through the nitrogen atom of triazine ring and nitrogen atoms of (pyrimidine, thiazole, and triazole) rings towards metal ion. The cytotoxic IC50 results of the free L-n ligands and its selenium (IV) complexes in vitro against the human colon and lung cancer cell lines introduced a promising efficiency. (C) 2018 Elsevier B.V. All rights reserved.