Presynaptic modulation of early olfactory processing in Drosophila

被引：23
作者：
Wang, Jing W. [1 ]
机构：
[1] Univ Calif San Diego, Neurobiol Sect, Div Biol Sci, La Jolla, CA 92093 USA
来源：
DEVELOPMENTAL NEUROBIOLOGY | 2012年 / 72卷 / 01期
基金：
美国国家科学基金会;
关键词：
neuromodulation; olfaction; NPY; GABA; tachykinin; TACHYKININ-RELATED PEPTIDES; SHORT NEUROPEPTIDE-F; MOTH MANDUCA-SEXTA; ANTENNAL LOBE; ODORANT RECEPTORS; SENSORY INPUT; FOOD-INTAKE; PROJECTION NEURONS; GABA(B) RECEPTORS; GENE-EXPRESSION;
D O I：
10.1002/dneu.20936
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Most animals are endowed with an olfactory system that is essential for finding foods, avoiding predators, and locating mating partners. The olfactory system must encode the identity and intensity of behaviorally relevant stimuli in a dynamic environmental landscape. How is olfactory information represented? How is a large dynamic range of odor concentrations represented in the olfactory system? How is this representation modulated to meet the demands of different internal physiological states? Recent studies have found that sensory terminals are important targets for neuromodulation. The emerging evidence suggests that presynaptic inhibition scales with sensory input and thus provides a mechanism to increase dynamic range of odor representation. In addition, presynaptic facilitation could be a mechanism to alter behavioral responses in hungry animals. This review will focus on the GABAB (gamma-aminobutyric acid) receptor-mediated presynaptic inhibition, and neuropeptide-mediated presynaptic modulation in Drosophila (c) 2011 Wiley Periodicals, Inc. Develop Neurobiol 72:8799, 2012
引用
收藏
页码：87 / 99
页数：13
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