Lacosamide-induced second-degree atrioventricular block in a patient with partial epilepsy

被引：71

作者：

Nizam, Ahmad ^{[1
]}

Mylavarapu, Krishna ^{[1
]}

Thomas, Dwithiya ^{[2
]}

Briskin, Klara ^{[1
]}

Wu, Brenda ^{[1
]}

Saluja, Deepak ^{[2
]}

Wong, Stephen ^{[1
]}

机构：

[1] UMDNJ Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08901 USA

[2] UMDNJ Robert Wood Johnson Med Sch, Div Cardiol, Dept Med, New Brunswick, NJ 08901 USA

来源：

EPILEPSIA | 2011年 / 52卷 / 10期

关键词：

Lacosamide; Heart block; Arrhythmia; PARTIAL-ONSET SEIZURES; ORAL LACOSAMIDE; EFFICACY; SAFETY;

D O I：

10.1111/j.1528-1167.2011.03212.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dose-dependent PR interval prolongation has been reported in preclinical studies of lacosamide ( LCM), a recently U. S. Food and Drug Administration ( FDA)-approved antiepileptic drug (AED). Here we report a case of second-degree atrioventricular block (AV) block caused by the addition of LCM to other AEDs known to prolong the PR interval, resulting in hypotension and bradycardia, with consequent seizure exacerbation. The patient recovered completely after withdrawal of LCM. This case demonstrates the need for caution and interval cardiac testing when adding LCM to other AEDs known to prolong the PR interval.

引用

页码：E153 / E155

页数：3