Gut Microbiota: Association with NAFLD and Metabolic Disturbances

被引：63

作者：

Lau, E. ^{[1
]}

Carvalho, D. ^{[1
]}

Freitas, P. ^{[1
]}

机构：

[1] Univ Porto, Fac Med, Ctr Hosp Sao Joao, Inst Res & Innovat Hlth Sci,Dept Endocrinol Diabe, P-4200319 Oporto, Portugal

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

FATTY LIVER-DISEASE; INTESTINAL BACTERIAL OVERGROWTH; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; OBESITY; ENDOTOXEMIA; DYSBIOSIS; PERMEABILITY;

D O I：

10.1155/2015/979515

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia. Recent lines of evidence have demonstrated a role of gut microbiota in insulin resistance, obesity, and associated metabolic disturbances, raising the interest in its relationship with NAFLD pathogenesis. Therefore, intestinal microbiota has emerged as a potential factor involved in NAFLD, through different pathways, including its influence in energy storage, lipid and choline metabolism, ethanol production, immune balance, and inflammation. The main objective of this review is to address the pathogenic association of gut microbiota to NAFLD. This comprehension may allow the development of integrated strategies to modulate intestinal microbiota in order to treat NAFLD.

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页数：9

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