Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents

被引：7

作者：

Piccardi, Riccardo ^{[1
]}

Coffinet, Anais ^{[1
]}

Benedetti, Erica ^{[1
]}

Turcaud, Serge ^{[1
]}

Micouin, Laurent ^{[1
]}

机构：

[1] Univ Paris 05, Fac Sci Fondamentales & Biomed, Lab Chim & Biochim Pharmacol & Toxicol, UMR CNRS 8601, 45 Rue St Peres, F-75006 Paris, France

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 19期

关键词：

organoaluminum; flow chemistry; metalation; alkynes; trimethylaluminum; ORGANIC-SYNTHESIS; FUNCTIONALIZED ARENES; CATALYZED ALUMINATION; ROOM-TEMPERATURE; CHEMISTRY; ELECTROPHILES; OXAZOLIDINES; MAGNESIATION; REACTIVITY; ACRYLATES;

D O I：

10.1055/s-0035-1561484

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new process for the synthesis of dimethylalkynylaluminum reagents under flow conditions is described. It involves a base-catalyzed alumination of terminal alkynes using a resin-supported organocatalyst. Final organometallic species are obtained in solution, and can further react with various aldehydes or nitrones.

引用

页码：3272 / 3278

页数：7

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