Opinion - Therapeutic vaccination for chronic diseases: a new class of drugs in sight

被引：91
作者：
Bachmann, MF [1 ]
Dyer, MR [1 ]
机构：
[1] Cytos Biotechnol AG, Schlieren, Switzerland
来源：
NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 01期
关键词：
D O I：
10.1038/nrd1284
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The induction of antibodies by prophylactic vaccination against infectious diseases has been the most effective medical intervention in human history. More recently, monoclonal antibodies specific for host proteins have proven to be highly effective for the treatment of acute and chronic diseases. However, the costs of protein therapies and their inconvenience for the patient are major obstacles for their widespread use. We suggest that the movement from the passive administration of monoclonal antibodies to active vaccination against self-molecules could be the next logical step in drug development, providing affordable medicines and broader patient acceptance and compliance.
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收藏
页码：81 / 88A
页数：8
相关论文
共 57 条
[31]   Human therapeutic cocaine vaccine: safety and immunogenicity [J].
Kosten, TR ;
Rosen, M ;
Bond, J ;
Settles, M ;
St Clair Roberts, J ;
Shields, J ;
Jack, L ;
Fox, B .
VACCINE, 2002, 20 (7-8) :1196-1204
[32]   Active immunization against nicotine prevents reinstatement of nicotine-seeking behavior in rats [J].
Lindblom, N ;
de Villiers, SHL ;
Kalayanov, G ;
Gordon, S ;
Johansson, AM ;
Svensson, TH .
RESPIRATION, 2002, 69 (03) :254-260
[33]   Humoral immunity and long-lived plasma cells [J].
Manz, RA ;
Arce, S ;
Cassese, G ;
Hauser, AE ;
Hiepe, F ;
Radbruch, A .
CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (04) :517-521
[34]   B cell memory and the long-lived plasma cell [J].
McHeyzer-Williams, MG ;
Ahmed, R .
CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (02) :172-179
[35]  
Miller N H, 1997, Am J Med, V102, P43
[36]   Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease [J].
Morgan, D ;
Diamond, DM ;
Gottschall, PE ;
Ugen, KE ;
Dickey, C ;
Hardy, J ;
Duff, K ;
Jantzen, P ;
DiCarlo, G ;
Wilcock, D ;
Connor, K ;
Hatcher, J ;
Hope, C ;
Gordon, M ;
Arendash, GW .
NATURE, 2000, 408 (6815) :982-985
[37]   CLONAL DELETION OF AUTOSPECIFIC LYMPHOCYTES-B [J].
NEMAZEE, D ;
RUSSELL, D ;
ARNOLD, B ;
HAEMMERLING, G ;
ALLISON, J ;
MILLER, JFAP ;
MORAHAN, G ;
BUERKI, K .
IMMUNOLOGICAL REVIEWS, 1991, 122 :117-132
[38]   Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide:: a case report [J].
Nicoll, JAR ;
Wilkinson, D ;
Holmes, C ;
Steart, P ;
Markham, H ;
Weller, RO .
NATURE MEDICINE, 2003, 9 (04) :448-452
[39]   Recent advances in the discovery and delivery of vaccine adjuvants [J].
O'Hagan, DT ;
Valiante, NM .
NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (09) :727-735
[40]   Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization [J].
Orgogozo, JM ;
Gilman, S ;
Dartigues, JF ;
Laurent, B ;
Puel, M ;
Kirby, LC ;
Jouanny, P ;
Dubois, B ;
Eisner, L ;
Flitman, S ;
Michel, BF ;
Boada, M ;
Frank, A ;
Hock, C .
NEUROLOGY, 2003, 61 (01) :46-54
123456